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Expression of a conserved cell-type-specific protein in nerve-terminals coincides with synaptogenesis

Academic Article
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Overview

authors

  • Blomqvist, A.
  • Catsicas, S.
  • Larhammar, D.
  • Milner, R, J.
  • Sanna, Pietro
  • Wilson, M. C.

publication date

  • February 1991

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Contact of axons with target territories results in the formation of synapses, specific junctional complexes that may represent a final stage of neuronal maturation. Synaptosomal-associated protein 25 (SNAP-25) is a component of particular nerve terminals recently identified in rodent brain. To evaluate the structure and regulation of molecular components of the synapse, we investigated the expression of SNAP-25 in the developing chicken nervous system. Analysis of SNAP-25 cDNA clones demonstrated that the chicken homologue is identical in amino acid sequence to the mouse protein. In chicken retina and neural tube, the onset of SNAP-25 mRNA and protein expression was found to correspond to the time of synaptogenesis. These results suggest that SNAP-25 plays a role in the physiology of mature nerve terminals and that its expression may be regulated by specific cell-cell interactions occurring during synapse formation.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain
  • Chick Embryo
  • Chickens
  • Cloning, Molecular
  • Ganglia, Spinal
  • Gene Library
  • Immunoblotting
  • Immunohistochemistry
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Nerve Endings
  • Nerve Tissue Proteins
  • Neurons
  • Nucleic Acid Hybridization
  • RNA, Messenger
  • Retina
  • Sequence Homology, Nucleic Acid
  • Spinal Cord
  • Synaptosomal-Associated Protein 25
  • Synaptosomes
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.88.3.785

PubMed ID

  • 1992470
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Additional Document Info

start page

  • 785

end page

  • 789

volume

  • 88

issue

  • 3

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