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Chemical strategies for activity-based proteomics

Academic Article
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Overview

related to degree

  • Speers, Anna, Ph.D. in Chemistry, Scripps Research 2000 - 2005

authors

  • Speers, Anna
  • Cravatt, Benjamin

publication date

  • January 2004

journal

  • ChemBioChem  Journal

abstract

  • The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.

subject areas

  • Animals
  • Drug Delivery Systems
  • Drug Design
  • Enzyme Inhibitors
  • Enzymes
  • Humans
  • Protein Engineering
  • Proteomics
  • Structure-Activity Relationship
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Research

keywords

  • activity-based profiling
  • enzymes
  • inhibitors
  • probes
  • proteomics
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Identity

International Standard Serial Number (ISSN)

  • 1439-4227

Digital Object Identifier (DOI)

  • 10.1002/cbic.200300721

PubMed ID

  • 14695510
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Additional Document Info

start page

  • 41

end page

  • 47

volume

  • 5

issue

  • 1

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