related to degree

• Speers, Anna, Ph.D. in Chemistry, Scripps Research 2000 - 2005

authors

• Speers, Anna
• Cravatt, Benjamin

publication date

• 2004

journal

• ChemBioChem  Journal

abstract

• The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.

subject areas

• Animals
• Drug Delivery Systems
• Drug Design
• Enzyme Inhibitors
• Enzymes
• Humans
• Protein Engineering
• Proteomics
• Structure-Activity Relationship

keywords

• activity-based profiling
• enzymes
• inhibitors
• probes
• proteomics

International Standard Serial Number (ISSN)

• 1439-4227

Digital Object Identifier (DOI)

• 10.1002/cbic.200300721

PubMed ID

• 14695510

start page

• 41

end page

• 47

volume

• 5

issue

• 1