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D3 receptor test in vitro predicts decreased cocaine self-administration in rats

Academic Article
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Overview

authors

  • Caine, S. B.
  • Koob, George
  • Parsons, Loren (Larry)
  • Everitt, B. J.
  • Schwartz, J. C.
  • Sokoloff, P.

publication date

  • 1997

journal

  • Neuroreport  Journal

abstract

  • The three dopamine agonists with highest reported D3 receptor selectivity in vitro, pramipexole, quinelorane and PD128,907, decreased self-administration of a high dose of cocaine in rats as a result of a leftward shift in the cocaine dose-effect function. In contrast the D3 preferring antagonist nafadotride increased cocaine self-administration. Moreover the relative potencies of these and other D2-like dopamine agonists (lisuride, 7-OH-DPAT, quinpirole, apomorphine, bromocriptine) to modulate cocaine self-administration were highly correlated with their relative potencies for increasing mitogenesis in vitro in cell lines expressing D3 but not D2 receptors. These results support the hypothesis that the D3 receptor may be an important target for pharmacotherapies for cocaine abuse and dependence.

subject areas

  • Animals
  • Benzopyrans
  • Benzothiazoles
  • Cocaine
  • Dopamine Agonists
  • Dopamine Antagonists
  • In Vitro Techniques
  • Male
  • Naphthalenes
  • Opioid-Related Disorders
  • Oxazines
  • Pyrrolidines
  • Quinolines
  • Rats
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Self Administration
  • Thiazoles
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Research

keywords

  • PD 128,907
  • cocaine
  • dopamine receptor
  • drug abuse
  • mitogenesis
  • nafadotride
  • pramipexole
  • quinelorane
  • rat
  • self-administration
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Identity

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199707070-00054

PubMed ID

  • 9243643
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Additional Document Info

start page

  • 2373

end page

  • 2377

volume

  • 8

issue

  • 9-10

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