recent publications
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academic article
- Zhang, K. X., Rao, F. W., Miramontes-Gonzalez, J. P., Hightower, C. M., Vaught, B., Chen, Y. H., Greenwood, T. A., Schork, A. J., Wang, L., Mahata, M., Stridsberg, M., Khandrika, S., et al. Neuropeptide y (npy) genetic variation in the human promoter alters glucocorticoid signaling, yielding increased npy secretion and stress responses Journal of the American College of Cardiology 2012 60:1678-1689 DOI:10.1016/j.jacc.2012.06.042 PMID:23021333 PMCID:PMC3687554
- Mbewe-Campbell, N., Wei, Z. Y., Zhang, K. X., Friese, R. S., Mahata, M., Schork, A. J., Rao, F. W., Chiron, S., Biswas, N., Kim, H. S., Mahata, S. K., Waalen, J., et al. Genes and environment: Novel, functional polymorphism in the human cathepsin l (ctsl1) promoter disrupts a xenobiotic response element (xre) to alter transcription and blood pressure Journal of Hypertension 2012 30:1961-1969 DOI:10.1097/HJH.0b013e328356b86a PMID:22871890 PMCID:PMC3478326
- Rao, F. W., Chiron, S., Wei, Z. Y., Fung, M. M., Chen, Y. Q., Wen, G., Khandrika, S., Ziegler, M. G., Benyamin, B., Montgomery, G., Whitfield, J. B., Martin, N. G., et al. Genetic variation within a metabolic motif in the chromogranin a promoter: Pleiotropic influence on cardiometabolic risk traits in twins American Journal of Hypertension 2012 25:29-40 DOI:10.1038/ajh.2011.163 PMID:21918574 PMCID:PMC3664223
- Chen, Y. Q., Zhang, K. X., Wen, G., Rao, F. W., Sanchez, A. P., Wang, L., Rodriguez-Flores, J. L., Mahata, M., Mahata, S. K., Waalen, J., Ziegler, M. G., Hamilton, B. A., et al. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure American Journal of Hypertension 2011 24:24-32 DOI:10.1038/ajh.2010.186 PMID:20814407 PMCID:PMC4906639
- Zhang, K. X., Rao, F. W., Wang, L., Rana, B. K., Ghosh, S., Mahata, M., Salem, R. M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Tayo, B., Taupenot, L., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension Journal of the American College of Cardiology 2010 55:1463-1475 DOI:10.1016/j.jacc.2009.11.064 PMID:20359597 PMCID:PMC2889490
- Chen, Y. Q., Salem, R. M., Rao, F. W., Fung, M. M., Bhatnagar, V., Pandey, B., Mahata, M., Waalen, J., Nievergelt, C. M., Lipkowitz, M. S., Hamilton, B. A., Mahata, S. K., et al. Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease American Journal of Nephrology 2010 32:414-424 DOI:10.1159/000320131 PMID:20861615 PMCID:PMC2975731
- Chen, Y. Q., Wen, G., Rao, F. W., Zhang, K. X., Wang, L., Rodriguez-Flores, J. L., Sanchez, A. P., Mahata, M., Taupenot, L., Sun, P., Mahata, S. K., Tayo, B., et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Journal of Hypertension 2010 28:76-86 DOI:10.1097/HJH.0b013e328332bc87 PMID:20009769 PMCID:PMC2860271
- Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Fung, M. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Hicks, P. J., Bowden, D. W., et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis American Journal of Nephrology 2010 32:23-30 DOI:10.1159/000313927 PMID:20484896 PMCID:PMC2914391
- Fung, M. M., Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Brophy, V. H., O'Connor, D. T., et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis Nephrology Dialysis Transplantation 2009 24:3677-3686 DOI:10.1093/ndt/gfp471 PMID:19745105 PMCID:PMC2790952
- Fung, M. M., Rana, B. K., Tang, C. M., Shiina, T., Nievergelt, C. M., Rao, F. W., Salem, R. M., Waalen, J., Ziegler, M. G., Insel, P. A., O'Connor, D. T. Dopamine d1 receptor (drd1) genetic polymorphism: Pleiotropic effects on heritable renal traits Kidney International 2009 76:1070-1080 DOI:10.1038/ki.2009.306 PMID:19675531 PMCID:PMC2803094
- Rana, B. K., Wessel, J., Mahboubi, V., Rao, F. W., Haeller, J., Gayen, J. R., Eskin, E., Valle, A. M., Das, M., Mahata, S. K., Taupenot, L., Stridsberg, M., et al. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: Influence on heritable autonomic traits in twin pairs Journal of Pharmacology and Experimental Therapeutics 2009 331:419-428 DOI:10.1124/jpet.109.157271 PMID:19671882 PMCID:PMC2775266
- Wang, L., Rao, F. W., Zhang, K. X., Mahata, M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Cockburn, M. G., Hamilton, B. A., Mahata, S. K., O'Connor, D. T. Neuropeptide y(1) receptor npy1r discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo Journal of the American College of Cardiology 2009 54:944-954 DOI:10.1016/j.jacc.2009.05.035 PMID:19712806 PMCID:PMC2792636
- Zhang, K. X., Rao, F. W., Rana, B. K., Gayen, J. R., Calegari, F., King, A., Rosa, P., Huttner, W. B., Stridsberg, M., Mahata, M., Vaingankar, S., Mahboubi, V., et al. Autonomic function in hypertension role of genetic variation at the catecholamine storage vesicle protein chromogranin b Circulation-Cardiovascular Genetics 2009 2:46-56 DOI:10.1161/circgenetics.108.785659 PMID:20011129 PMCID:PMC2792940
- Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology 2008 52:1468-1481 DOI:10.1016/j.jacc.2008.07.047 PMID:19017515 PMCID:PMC2659417
- Rao, F. W., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y. Q., Khandrika, S., Hamilton, B. A., Smith, D. W., et al. Renal albumin excretion - twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism Hypertension 2007 49:1015-1031 DOI:10.1161/hypertensionaha.106.081679 PMID:17353515
- Greenwood, T. A., Rao, F. W., Stridsberg, M., Mahapatra, N. R., Mahata, M., Lillie, E. O., Mahata, S. K., Taupenot, L., Schork, N. J., O'Connor, D. T. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion Physiological Genomics 2006 25:470-479 DOI:10.1152/physiolgenomics.00295.2005 PMID:16554546
- Seasholtz, T. M., Wessel, J., Rao, F. W., Rana, B. K., Khandrika, S., Kennedy, B. P., Lillie, E. O., Ziegler, M. G., Smith, D. W., Schork, N. J., Brown, J. H., O'Connor, D. T. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins - role of heredity Hypertension 2006 47:937-947 DOI:10.1161/01.HYP.0000217364.45622.f0 PMID:16585408
- Bao, X. P., Mills, P. J., Rana, B. K., Dimsdale, J. E., Schork, N. J., Smith, D. W., Rao, F. W., Milic, M., O'Connor, D. T., Ziegler, M. G. Interactive effects of common beta(2)-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function Hypertension 2005 46:301-307 DOI:10.1161/01.hyp.0000175842.19266.95 PMID:16027244
- King, D., Etzel, J. P., Chopra, S., Smith, J., Cadman, P. E., Rao, F. W., Funk, S. D., Rana, B. K., Schork, N. J., Insel, P. A., O'Connor, D. T. Human response to alpha(2)-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype Clinical Pharmacology & Therapeutics 2005 77:388-403 DOI:10.1016/j.clpt.2005.02.008 PMID:15900285
- Zhang, L., Rao, F. W., Wessel, J., Kennedy, B. P., Rana, B. K., Taupenot, L., Lillie, E. O., Cockburn, M., Schork, N. J., Ziegler, M. G., O'Connor, D. T. Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: Prediction of catecholamines and response to stress in twins Physiological Genomics 2004 19:277-291 DOI:10.1152/physiolgenomics.00151.2004 PMID:15367723
- Wen, G., Mahata, S. K., Cadman, P., Mahata, M., Ghosh, S., Mahapatra, N. R., Rao, F. W., Stridsberg, M., Smith, D. W., Mahboubi, P., Schork, N. J., O'Connor, D. T., et al. Both rare and common polymorphisms contribute functional variation at chga, a regulator of catecholamine physiology American Journal of Human Genetics 2004 74:197-207 DOI:10.1086/381399 PMID:14740315 PMCID:PMC1181918