recent publications

• academic article

  • Zhang, K. X., Rao, F. W., Miramontes-Gonzalez, J. P., Hightower, C. M., Vaught, B., Chen, Y. H., Greenwood, T. A., Schork, A. J., Wang, L., Mahata, M., Stridsberg, M., Khandrika, S., et al. Neuropeptide y (npy) genetic variation in the human promoter alters glucocorticoid signaling, yielding increased npy secretion and stress responses Journal of the American College of Cardiology  2012 60:1678-1689  DOI:10.1016/j.jacc.2012.06.042  PMID:23021333  PMCID:PMC3687554
  • Mbewe-Campbell, N., Wei, Z. Y., Zhang, K. X., Friese, R. S., Mahata, M., Schork, A. J., Rao, F. W., Chiron, S., Biswas, N., Kim, H. S., Mahata, S. K., Waalen, J., et al. Genes and environment: Novel, functional polymorphism in the human cathepsin l (ctsl1) promoter disrupts a xenobiotic response element (xre) to alter transcription and blood pressure Journal of Hypertension  2012 30:1961-1969  DOI:10.1097/HJH.0b013e328356b86a  PMID:22871890  PMCID:PMC3478326
  • Rao, F. W., Chiron, S., Wei, Z. Y., Fung, M. M., Chen, Y. Q., Wen, G., Khandrika, S., Ziegler, M. G., Benyamin, B., Montgomery, G., Whitfield, J. B., Martin, N. G., et al. Genetic variation within a metabolic motif in the chromogranin a promoter: Pleiotropic influence on cardiometabolic risk traits in twins American Journal of Hypertension  2012 25:29-40  DOI:10.1038/ajh.2011.163  PMID:21918574  PMCID:PMC3664223
  • Chen, Y. Q., Zhang, K. X., Wen, G., Rao, F. W., Sanchez, A. P., Wang, L., Rodriguez-Flores, J. L., Mahata, M., Mahata, S. K., Waalen, J., Ziegler, M. G., Hamilton, B. A., et al. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure American Journal of Hypertension  2011 24:24-32  DOI:10.1038/ajh.2010.186  PMID:20814407  PMCID:PMC4906639
  • Zhang, K. X., Rao, F. W., Wang, L., Rana, B. K., Ghosh, S., Mahata, M., Salem, R. M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Tayo, B., Taupenot, L., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension Journal of the American College of Cardiology  2010 55:1463-1475  DOI:10.1016/j.jacc.2009.11.064  PMID:20359597  PMCID:PMC2889490
  • Chen, Y. Q., Salem, R. M., Rao, F. W., Fung, M. M., Bhatnagar, V., Pandey, B., Mahata, M., Waalen, J., Nievergelt, C. M., Lipkowitz, M. S., Hamilton, B. A., Mahata, S. K., et al. Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease American Journal of Nephrology  2010 32:414-424  DOI:10.1159/000320131  PMID:20861615  PMCID:PMC2975731
  • Chen, Y. Q., Wen, G., Rao, F. W., Zhang, K. X., Wang, L., Rodriguez-Flores, J. L., Sanchez, A. P., Mahata, M., Taupenot, L., Sun, P., Mahata, S. K., Tayo, B., et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Journal of Hypertension  2010 28:76-86  DOI:10.1097/HJH.0b013e328332bc87  PMID:20009769  PMCID:PMC2860271
  • Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Fung, M. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Hicks, P. J., Bowden, D. W., et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis American Journal of Nephrology  2010 32:23-30  DOI:10.1159/000313927  PMID:20484896  PMCID:PMC2914391
  • Fung, M. M., Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Brophy, V. H., O'Connor, D. T., et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis Nephrology Dialysis Transplantation  2009 24:3677-3686  DOI:10.1093/ndt/gfp471  PMID:19745105  PMCID:PMC2790952
  • Fung, M. M., Rana, B. K., Tang, C. M., Shiina, T., Nievergelt, C. M., Rao, F. W., Salem, R. M., Waalen, J., Ziegler, M. G., Insel, P. A., O'Connor, D. T. Dopamine d1 receptor (drd1) genetic polymorphism: Pleiotropic effects on heritable renal traits Kidney International  2009 76:1070-1080  DOI:10.1038/ki.2009.306  PMID:19675531  PMCID:PMC2803094
  • Rana, B. K., Wessel, J., Mahboubi, V., Rao, F. W., Haeller, J., Gayen, J. R., Eskin, E., Valle, A. M., Das, M., Mahata, S. K., Taupenot, L., Stridsberg, M., et al. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: Influence on heritable autonomic traits in twin pairs Journal of Pharmacology and Experimental Therapeutics  2009 331:419-428  DOI:10.1124/jpet.109.157271  PMID:19671882  PMCID:PMC2775266
  • Wang, L., Rao, F. W., Zhang, K. X., Mahata, M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Cockburn, M. G., Hamilton, B. A., Mahata, S. K., O'Connor, D. T. Neuropeptide y(1) receptor npy1r discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo Journal of the American College of Cardiology  2009 54:944-954  DOI:10.1016/j.jacc.2009.05.035  PMID:19712806  PMCID:PMC2792636
  • Zhang, K. X., Rao, F. W., Rana, B. K., Gayen, J. R., Calegari, F., King, A., Rosa, P., Huttner, W. B., Stridsberg, M., Mahata, M., Vaingankar, S., Mahboubi, V., et al. Autonomic function in hypertension role of genetic variation at the catecholamine storage vesicle protein chromogranin b Circulation-Cardiovascular Genetics  2009 2:46-56  DOI:10.1161/circgenetics.108.785659  PMID:20011129  PMCID:PMC2792940
  • Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology  2008 52:1468-1481  DOI:10.1016/j.jacc.2008.07.047  PMID:19017515  PMCID:PMC2659417
  • Rao, F. W., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y. Q., Khandrika, S., Hamilton, B. A., Smith, D. W., et al. Renal albumin excretion - twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism Hypertension  2007 49:1015-1031  DOI:10.1161/hypertensionaha.106.081679  PMID:17353515
  • Greenwood, T. A., Rao, F. W., Stridsberg, M., Mahapatra, N. R., Mahata, M., Lillie, E. O., Mahata, S. K., Taupenot, L., Schork, N. J., O'Connor, D. T. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion Physiological Genomics  2006 25:470-479  DOI:10.1152/physiolgenomics.00295.2005  PMID:16554546
  • Seasholtz, T. M., Wessel, J., Rao, F. W., Rana, B. K., Khandrika, S., Kennedy, B. P., Lillie, E. O., Ziegler, M. G., Smith, D. W., Schork, N. J., Brown, J. H., O'Connor, D. T. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins - role of heredity Hypertension  2006 47:937-947  DOI:10.1161/01.HYP.0000217364.45622.f0  PMID:16585408
  • Bao, X. P., Mills, P. J., Rana, B. K., Dimsdale, J. E., Schork, N. J., Smith, D. W., Rao, F. W., Milic, M., O'Connor, D. T., Ziegler, M. G. Interactive effects of common beta(2)-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function Hypertension  2005 46:301-307  DOI:10.1161/01.hyp.0000175842.19266.95  PMID:16027244
  • King, D., Etzel, J. P., Chopra, S., Smith, J., Cadman, P. E., Rao, F. W., Funk, S. D., Rana, B. K., Schork, N. J., Insel, P. A., O'Connor, D. T. Human response to alpha(2)-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype Clinical Pharmacology & Therapeutics  2005 77:388-403  DOI:10.1016/j.clpt.2005.02.008  PMID:15900285
  • Zhang, L., Rao, F. W., Wessel, J., Kennedy, B. P., Rana, B. K., Taupenot, L., Lillie, E. O., Cockburn, M., Schork, N. J., Ziegler, M. G., O'Connor, D. T. Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: Prediction of catecholamines and response to stress in twins Physiological Genomics  2004 19:277-291  DOI:10.1152/physiolgenomics.00151.2004  PMID:15367723
  • Wen, G., Mahata, S. K., Cadman, P., Mahata, M., Ghosh, S., Mahapatra, N. R., Rao, F. W., Stridsberg, M., Smith, D. W., Mahboubi, P., Schork, N. J., O'Connor, D. T., et al. Both rare and common polymorphisms contribute functional variation at chga, a regulator of catecholamine physiology American Journal of Human Genetics  2004 74:197-207  DOI:10.1086/381399  PMID:14740315  PMCID:PMC1181918