recent publications

• academic article

  • Yoneyama, S., Guo, Y., Lanktree, M. B., Barnes, M. R., Elbers, C. C., Karczewski, K. J., Padmanabhan, S., Bauer, F., Baumert, J., Beitelshees, A., Berenson, G. S., Boer, J. M. A., et al. Gene-centric meta-analyses for central adiposity traits in up to 57,412 individuals of European descent confirm known loci and reveal several novel associations Human Molecular Genetics  2014 23:2498-2510  DOI:10.1093/hmg/ddt626  PMID:24345515  PMCID:PMC3988452
  • Ganesh, S. K., Tragante, V., Guo, W., Guo, Y. R., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array Human Molecular Genetics  2013 22:1663-1678  DOI:10.1093/hmg/dds555  PMID:23303523  PMCID:PMC3657476
  • Asselbergs, F. W., Guo, Y. R., van Iperen, E. P. A., Sivapalaratnam, S., Tragante, V., Lanktree, M. B., Lange, L. A., Almoguera, B., Appelman, Y. E., Barnard, J., Baumert, J., Beitelshees, A. L., et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci American Journal of Human Genetics  2012 91:823-838  DOI:10.1016/j.ajhg.2012.08.032  PMID:23063622  PMCID:PMC3487124
  • Han, J., Baik, N., Kim, K. H., Yang, J. M., Han, G. W., Gong, Y., Jardi, M., Castellino, F. J., Felez, J., Parmer, R. J., Miles, L. A. Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen Blood  2011 118:1653-1662  DOI:10.1182/blood-2010-11-316943  PMID:21680799  PMCID:PMC3156051
  • Lanktree, M. B., Guo, Y. R., Murtaza, M., Glessner, J. T., Bailey, S. D., Onland-Moret, N. C., Lettre, G., Ongen, H., Rajagopalan, R., Johnson, T., Shen, H., Nelson, C. P., et al. Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height American Journal of Human Genetics  2011 88:6-18  DOI:10.1016/j.ajhg.2010.11.007  PMID:21194676  PMCID:PMC3014369
  • Beitelshees, A. L., Navare, H., Wang, D. X., Gong, Y., Wessel, J., Moss, J. I., Langaee, T. Y., Cooper-DeHoff, R. M., Sadee, W., Pepine, C. J., Schork, N. J., Johnson, J. A. Cacna1c gene polymorphisms, cardiovascular disease outcomes, and treatment response Circulation-Cardiovascular Genetics  2009 2:362-370  DOI:10.1161/circgenetics.109.857839  PMID:20031608  PMCID:PMC2761685
  • Johnson, A. D., Gong, Y., Wang, D., Langaee, T. Y., Shin, J., Cooper-DeHoff, R. M., Schork, N. J., Binkley, P., Pepine, C. J., Johnson, J. A., Sadee, W. Promoter polymorphisms in ace (angiotensin i-converting enzyme) associated with clinical outcomes in hypertension Clinical Pharmacology & Therapeutics  2009 85:36-44  DOI:10.1038/clpt.2008.194  PMID:18946466  PMCID:PMC2709290
  • Pacanowski, M. A., Gong, Y., Cooper-DeHoff, R. M., Schork, N. J., Shriver, M. D., Langaee, T. Y., Pepine, C. J., Johnson, J. A., Investigators, Invest Beta-adrenergic receptor gene polymorphisms and beta-blocker treatment outcomes in hypertension Clinical Pharmacology & Therapeutics  2008 84:715-721  DOI:10.1038/clpt.2008.139  PMID:18615004  PMCID:PMC2675574
  • Gerhard, T., Gong, Y., Beitelshees, A. L., Mao, X., Lobmeyer, M. T., Cooper-DeHoff, R. M., Langaee, T. Y., Schork, N. J., Shriver, M. D., Pepine, C. J., Johnson, J. A., Investigators, Invest Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: Results from genetic substudy of the international verapamil sr-trandolapril study (invest-genes) American Heart Journal  2008 156:397-404  DOI:10.1016/j.ahj.2008.03.007  PMID:18657677  PMCID:PMC2547143
  • Beitelshees, A. L., Gong, Y., Wang, D., Schork, N. J., Cooper-DeHoff, R. M., Langaee, T. Y., Shriver, M. D., Sadee, W., Knot, H. J., Pepine, C. J., Johnson, J. A., Investigators, Invest Kcnmb1 genotype influences response to verapamil sir and adverse outcomes in the international verapamil sr/trandolapril study (invest) Pharmacogenetics and Genomics  2007 17:719-729  DOI:10.1097/FPC.0b013e32810f2e3c  PMID:17700361  PMCID:PMC2713584
  • Gong, Y., Beitelshees, A. L., Wessel, J., Langaee, T. Y., Schork, N. J., Johnson, J. A. Single nucleotide polymorphism discovery and haplotype analysis of ca2+-dependent k+ channel beta-1 subunit Pharmacogenetics and Genomics  2007 17:267-275  DOI:10.1097/FPC.0b013e3280105235  PMID:17496725  PMCID:PMC2713575
  • Zhang, L., Gong, Y., Grella, D. K., Castellino, F. J., Miles, L. A. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface Journal of Thrombosis and Haemostasis  2003 1:1264-1270  DOI:10.1046/j.1538-7836.2003.00155.x  PMID:12871329
  • Miles, L. A., Castellino, F. J., Gong, Y. Critical role for conversion of Glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces Trends in Cardiovascular Medicine  2003 13:21-30  DOI:10.1016/s1050-1738(02)00190-1  PMID:12554097
  • Gong, Y., Kim, S. O., Felez, J., Grella, D. K., Castellino, F. J., Miles, L. A. Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface Journal of Biological Chemistry  2001 276:19078-19083  DOI:10.1074/jbc.M101387200  PMID:11264290
  • Parmer, R. J., Mahata, M., Gong, Y., Mahata, S. K., Jiang, Q. J., O'Connor, D. T., Xi, X. P., Miles, L. A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion Journal of Clinical Investigation  2000 106:907-915  DOI:10.1172/jci7394  PMID:11018079  PMCID:PMC381423
  • Parmer, R. J., Mahata, S. K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O'Connor, D. T., Miles, L. A. Tissue plasminogen activator and chromaffin cell function Advances in Experimental Medicine and Biology  2000 482:179-192  DOI:10.1007/0-306-46837-9_14  PMID:11192579