Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Human immunodeficiency virus infection of human-PBL-SCID mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mosier, Donald
  • Gulizia, R. J.
  • Baird, S. M.
  • Wilson, D. B.
  • Spector, D. H.
  • Spector, S. A.

publication date

  • February 1991

journal

  • Science  Journal

abstract

  • Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.

subject areas

  • Animals
  • Blood Transfusion
  • Chimera
  • Disease Models, Animal
  • HIV Infections
  • HIV-1
  • Humans
  • Immunologic Deficiency Syndromes
  • Lymphocyte Transfusion
  • Mice
  • Mice, Mutant Strains
  • Spleen
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1990441

PubMed ID

  • 1990441
scroll to property group menus

Additional Document Info

start page

  • 791

end page

  • 794

volume

  • 251

issue

  • 4995

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support