Asymmetric wolff rearrangement reactions with alpha-alkylated-alpha-diazoketones: Stereoselective synthesis of alpha-substituted-beta-amino acid derivatives

Academic Article
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publication date

  • July 2000

abstract

  • Photoinduced asymmetric Wolff rearrangement reactions were performed with alpha-amino-alpha'-methyl-alpha'-diazoketones to afford alpha-methyl-beta-amino acid esters with good stereoselectivity. Factors that may influence the stereochemistry were examined, including steric effects and temperature dependence, which had a great impact on the stereochemistry.