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Fatty acid amide hydrolase substrate specificity

Academic Article
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Overview

related to degree

  • Patricelli, Matt, Ph.D. in Biology, Scripps Research 1996 - 2000
  • Patterson, Jean, Ph.D. in Chemistry, Scripps Research 1992 - 1997

authors

  • Boger, Dale
  • Fecik, R. A.
  • Patterson, Jean
  • Miyauchi, H.
  • Patricelli, Matt
  • Cravatt, Benjamin

publication date

  • December 2000

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH.

subject areas

  • Amidohydrolases
  • Animals
  • Hydrolysis
  • Rats
  • Recombinant Proteins
  • Substrate Specificity
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(00)00528-x

PubMed ID

  • 11128635
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Additional Document Info

start page

  • 2613

end page

  • 2616

volume

  • 10

issue

  • 23

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