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Tyrosine kinase is involved in hemin-induced pyresis

Academic Article
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Overview

authors

  • Lee, S. H.
  • Jang, Choon-Gon
  • Lee, S. Y.

publication date

  • May 2003

journal

  • Archives of Pharmacal Research  Journal

abstract

  • To investigate the mechanisms involved in hemin-induced febrile response, the rectal temperature of rats were measured after intracerebroventricular (i.c.v.) injections of hemin, with or without antagonists. Hemin (10 microg) elicited a significant febrile response, which lasted from 30 min, to more than 6 h, after its administration, but this was not the case with biliverdin (i.c.v.) and bilirubin (i.c.v.). The hemin-induced febrile response was significantly inhibited by pretreatment with an inhibitor of tyrosine kinase (genistein), but not by pretreatment with an inhibitor of protein kinase C (chelerythrine) and a scavenger of iron (deferoxamine). These results suggest that tyrosine kinase is involved in the hemin-induced febrile response.

subject areas

  • Alkaloids
  • Animals
  • Benzophenanthridines
  • Body Temperature
  • Deferoxamine
  • Fever
  • Genistein
  • Heme Oxygenase (Decyclizing)
  • Hemin
  • Injections, Intraventricular
  • Iron Chelating Agents
  • Male
  • Phenanthridines
  • Protein Kinase C
  • Protein-Tyrosine Kinases
  • Pyrogens
  • Rats
  • Rats, Sprague-Dawley
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Research

keywords

  • carbon monoxide
  • hemin
  • tyrosine kinase
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Identity

International Standard Serial Number (ISSN)

  • 0253-6269

Digital Object Identifier (DOI)

  • 10.1007/bf02976699

PubMed ID

  • 12785738
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Additional Document Info

start page

  • 411

end page

  • 415

volume

  • 26

issue

  • 5

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