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Cerebrodiene: A brain lipid isolated from sleep-deprived cats

Academic Article
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Overview

related to degree

  • Cravatt, Benjamin, Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1992 - 1996

authors

  • Lerner, Richard
  • Siuzdak, Gary
  • Prosperogarcia, O.
  • Henriksen, S. J.
  • Boger, Dale
  • Cravatt, Benjamin

publication date

  • September 1994

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

subject areas

  • Animals
  • Brain
  • Cats
  • Chromatography, High Pressure Liquid
  • Female
  • Mass Spectrometry
  • Molecular Structure
  • Sleep Deprivation
  • Sphingosine
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Identity

PubMed Central ID

  • PMC44841

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.91.20.9505

PubMed ID

  • 7937797
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Additional Document Info

start page

  • 9505

end page

  • 9508

volume

  • 91

issue

  • 20

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