related to degree

• Cravatt, Benjamin, Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1992 - 1996

authors

• Lerner, Richard
• Siuzdak, Gary
• Prosperogarcia, O.
• Henriksen, S. J.
• Boger, Dale
• Cravatt, Benjamin

publication date

• 1994

journal

• Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

• We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

subject areas

• Animals
• Brain
• Cats
• Chromatography, High Pressure Liquid
• Female
• Mass Spectrometry
• Molecular Structure
• Sleep Deprivation
• Sphingosine

PubMed Central ID

• PMC44841

International Standard Serial Number (ISSN)

• 0027-8424

Digital Object Identifier (DOI)

• 10.1073/pnas.91.20.9505

PubMed ID

• 7937797

start page

• 9505

end page

• 9508

volume

• 91

issue

• 20