recent publications
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academic article
- Perry, J. J. P., Hearn, A. S., Cabelli, D. E., Nick, H. S., Tainer, J. A., Silverman, D. N. Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis Biochemistry 2009 48:3417-3424 DOI:10.1021/bi8023288 PMID:19265433 PMCID:PMC2756076
- Ren, X. L., Tu, C. K., Bhatt, D., Perry, J. J. P., Tainer, J. A., Cabelli, D. E., Silverman, D. N. Kinetic and structural characterization of human manganese superoxide dismulase containing 3-fluorotyrosines Journal of Molecular Structure 2006 790:168-173 DOI:10.1016/j.molstruc.2005.10.054
- Greenleaf, W. B., Jefferson, J., Perry, P., Hearn, A. S., Cabelli, D. E., Lepock, J. R., Stroupe, M. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of hydrogen bonding in the active site of human manganese superoxide dismutase Biochemistry 2004 43:7038-7045 DOI:10.1021/bi049888k PMID:15170341
- Hearn, A. S., Fan, L., Lepock, J. R., Luba, J. P., Greenleaf, W. B., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Journal of Biological Chemistry 2004 279:5861-5866 DOI:10.1074/jbc.M311310200 PMID:14638684
- Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Ramilo, C. A., Luba, J. P., Tainer, J. A., Nick, H. S., Silverman, D. N. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel Biochemistry 2003 42:2781-2789 DOI:10.1021/bi0266481 PMID:12627943
- Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Lepock, J. R., Tainer, J. A., Nick, H. S., Silverman, D. N. Kinetic analysis of product inhibition in human manganese superoxide dismutase Biochemistry 2001 40:12051-12058 DOI:10.1021/bi011047f PMID:11580280
- Leveque, V. J. P., Stroupe, M. E., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis Biochemistry 2000 39:7131-7137 DOI:10.1021/bi9929958 PMID:10852710
- Cabelli, D. E., Guan, Y., Leveque, V., Hearn, A. S., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase Biochemistry 1999 38:11686-11692 DOI:10.1021/bi9909142 PMID:10512624
- Fisher, C. L., Cabelli, D. E., Hallewell, R. A., Beroza, P., Lo, T. P., Getzoff, E. D., Tainer, J. A. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase Proteins-Structure Function and Genetics 1997 29:103-112 DOI:10.1002/(sici)1097-0134(199709)29:1<103::aid-prot8>3.0.co;2-g PMID:9294870
- Boissinot, M., Karnas, S., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Getzoff, E. D., Hallewell, R. A. Function of the Greek key connection analysed using circular permutants of superoxide dismutase EMBO Journal 1997 16:2171-2178 DOI:10.1093/emboj/16.9.2171 PMID:9171332 PMCID:PMC1169819
- Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Johnson, M. J., Boissinot, M., Hallewell, R. A., Lepock, J. R., Cabelli, D. E., Tainer, J. A. Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Biochemistry 1996 35:4287-4297 DOI:10.1021/bi951892w PMID:8605177
- Fisher, C. L., Cabelli, D. E., Tainer, J. A., Hallewell, R. A., Getzoff, E. D. The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Proteins-Structure Function and Genetics 1994 19:24-34 DOI:10.1002/prot.340190105 PMID:8066083
- Banci, L., Cabelli, D. E., Getzoff, E. D., Hallewell, R. A., Viezzoli, M. S. An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Journal of Inorganic Biochemistry 1993 50:89-100 DOI:10.1016/0162-0134(93)80016-3 PMID:8098056
- Getzoff, E. D., Cabelli, D. E., Fisher, C. L., Parge, H. E., Viezzoli, M. S., Banci, L., Hallewell, R. A. Faster superoxide-dismutase mutants designed by enhancing electrostatic guidance Nature 1992 358:347-351 DOI:10.1038/358347a0 PMID:1353610
- Hallewell, R. A., Imlay, K. C., Lee, P., Fong, N. M., Gallegos, C., Getzoff, E. D., Tainer, J. A., Cabelli, D. E., Tekampolson, P., Mullenbach, G. T., Cousens, L. S. Thermostabilization of recombinant human and bovine Cu Zn superoxide dismutases by replacement of free cysteines Biochemical and Biophysical Research Communications 1991 181:474-480 DOI:10.1016/s0006-291x(05)81443-3 PMID:1958215