recent publications

• academic article

  • Perry, J. J. P., Hearn, A. S., Cabelli, D. E., Nick, H. S., Tainer, J. A., Silverman, D. N. Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis Biochemistry  2009 48:3417-3424  DOI:10.1021/bi8023288  PMID:19265433  PMCID:PMC2756076
  • Ren, X. L., Tu, C. K., Bhatt, D., Perry, J. J. P., Tainer, J. A., Cabelli, D. E., Silverman, D. N. Kinetic and structural characterization of human manganese superoxide dismulase containing 3-fluorotyrosines Journal of Molecular Structure  2006 790:168-173  DOI:10.1016/j.molstruc.2005.10.054
  • Hearn, A. S., Fan, L., Lepock, J. R., Luba, J. P., Greenleaf, W. B., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Journal of Biological Chemistry  2004 279:5861-5866  DOI:10.1074/jbc.M311310200  PMID:14638684
  • Greenleaf, W. B., Jefferson, J., Perry, P., Hearn, A. S., Cabelli, D. E., Lepock, J. R., Stroupe, M. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of hydrogen bonding in the active site of human manganese superoxide dismutase Biochemistry  2004 43:7038-7045  DOI:10.1021/bi049888k  PMID:15170341
  • Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Ramilo, C. A., Luba, J. P., Tainer, J. A., Nick, H. S., Silverman, D. N. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel Biochemistry  2003 42:2781-2789  DOI:10.1021/bi0266481  PMID:12627943
  • Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Lepock, J. R., Tainer, J. A., Nick, H. S., Silverman, D. N. Kinetic analysis of product inhibition in human manganese superoxide dismutase Biochemistry  2001 40:12051-12058  DOI:10.1021/bi011047f  PMID:11580280
  • Leveque, V. J. P., Stroupe, M. E., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis Biochemistry  2000 39:7131-7137  DOI:10.1021/bi9929958  PMID:10852710
  • Cabelli, D. E., Guan, Y., Leveque, V., Hearn, A. S., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase Biochemistry  1999 38:11686-11692  DOI:10.1021/bi9909142  PMID:10512624
  • Fisher, C. L., Cabelli, D. E., Hallewell, R. A., Beroza, P., Lo, T. P., Getzoff, E. D., Tainer, J. A. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase Proteins-Structure Function and Genetics  1997 29:103-112  DOI:10.1002/(sici)1097-0134(199709)29:1<103::aid-prot8>3.0.co;2-g  PMID:9294870
  • Boissinot, M., Karnas, S., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Getzoff, E. D., Hallewell, R. A. Function of the Greek key connection analysed using circular permutants of superoxide dismutase EMBO Journal  1997 16:2171-2178  DOI:10.1093/emboj/16.9.2171  PMID:9171332  PMCID:PMC1169819
  • Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Johnson, M. J., Boissinot, M., Hallewell, R. A., Lepock, J. R., Cabelli, D. E., Tainer, J. A. Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Biochemistry  1996 35:4287-4297  DOI:10.1021/bi951892w  PMID:8605177
  • Fisher, C. L., Cabelli, D. E., Tainer, J. A., Hallewell, R. A., Getzoff, E. D. The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Proteins-Structure Function and Genetics  1994 19:24-34  DOI:10.1002/prot.340190105  PMID:8066083
  • Banci, L., Cabelli, D. E., Getzoff, E. D., Hallewell, R. A., Viezzoli, M. S. An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Journal of Inorganic Biochemistry  1993 50:89-100  DOI:10.1016/0162-0134(93)80016-3  PMID:8098056
  • Getzoff, E. D., Cabelli, D. E., Fisher, C. L., Parge, H. E., Viezzoli, M. S., Banci, L., Hallewell, R. A. Faster superoxide-dismutase mutants designed by enhancing electrostatic guidance Nature  1992 358:347-351  DOI:10.1038/358347a0  PMID:1353610
  • Hallewell, R. A., Imlay, K. C., Lee, P., Fong, N. M., Gallegos, C., Getzoff, E. D., Tainer, J. A., Cabelli, D. E., Tekampolson, P., Mullenbach, G. T., Cousens, L. S. Thermostabilization of recombinant human and bovine Cu Zn superoxide dismutases by replacement of free cysteines Biochemical and Biophysical Research Communications  1991 181:474-480  DOI:10.1016/s0006-291x(05)81443-3  PMID:1958215