Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Bechmann, I.
  • Diano, S.
  • Warden, C. H.
  • Bartfai, Tamas
  • Nitsch, R.
  • Horvath, T. L.

publication date

  • August 2002

journal

  • Biochemical Pharmacology  Journal

abstract

  • Mitochondrial uncoupling proteins (UCPs) can dissociate oxidative phosphorylation from respiration, and they appear to be critical for energy balance. One of these proteins, UCP2, is also expressed in neurons of subcortical brain regions of healthy subjects. Here, we report on the protective role of UCP2 in brain injury by revealing its early induction after lesions and its inverse relationship with activation of an apoptotic signal, caspase 3, in wild-type and UCP2 overexpressing transgenic mice.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Brain Injuries
  • Disease Models, Animal
  • Entorhinal Cortex
  • Gene Transfer Techniques
  • Immunohistochemistry
  • Ion Channels
  • Learning
  • Male
  • Membrane Transport Proteins
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria
  • Mitochondrial Proteins
  • Nerve Degeneration
  • Neurons
  • Protective Agents
  • Proteins
  • Rats
  • Rats, Wistar
  • Signal Transduction
  • Stress, Physiological
scroll to property group menus

Research

keywords

  • brain injury
  • hippocampus
  • microglia
  • mitochondrial uncoupling proteins
  • neuronal degeneration
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0006-2952

Digital Object Identifier (DOI)

  • 10.1016/s0006-2952(02)01166-8

PubMed ID

  • 12147286
scroll to property group menus

Additional Document Info

start page

  • 363

end page

  • 367

volume

  • 64

issue

  • 3

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support