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Impairment of spatial but not contextual memory in camkii mutant mice with a selective loss of hippocampal ltp in the range of the theta-frequency

Academic Article
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Overview

authors

  • Beach, M. E.
  • Hawkins, R. D.
  • Osman, M.
  • Kandel, E. R.
  • Mayford, Mark

publication date

  • June 1995

journal

  • Cell  Journal

abstract

  • We assessed hippocampal-dependent memory in mice with a Ca(2+)-independent form of CaMKII generated by the introduction of an aspartate at amino acid 286. The CaMKII-Asp-286 mice show normal LTP at high frequency stimulation, but in the 5-10 Hz range, they show a shift in the frequency-response curve favoring LTD. This range of frequencies is similar to the theta rhythm, which is associated with exploration in rodents. Using the Barnes maze to assess spatial memory, we found the transgenic mice could not learn to navigate to a specific location using spatial cues. In contrast, one line of transgenic mice performed normally in contextual fear conditioning, a task that is also hippocampal dependent. This dissociation between spatial and contextual memory suggests that even though both require the hippocampus, they may be mediated by different synaptic mechanisms.

subject areas

  • Animals
  • Behavior, Animal
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Conditioning (Psychology)
  • Darkness
  • Electric Stimulation
  • Fear
  • Female
  • Hippocampus
  • Light
  • Long-Term Potentiation
  • Male
  • Maze Learning
  • Memory
  • Mice
  • Mice, Transgenic
  • Neuronal Plasticity
  • Point Mutation
  • Spatial Behavior
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

PubMed ID

  • 7781067
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Additional Document Info

start page

  • 905

end page

  • 915

volume

  • 81

issue

  • 6

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