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Opioid peptide identity and localization in hippocampus

Academic Article
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Overview

authors

  • McGinty, J. F.
  • Henriksen, S. J.
  • Goldstein, A.
  • Terenius, Lars
  • Bloom, Floyd

publication date

  • 1982

journal

  • Life Sciences  Journal

abstract

  • The hippocampus contains three times as much dynorphin-17 immunoreactivity (ir) as enkephalin-ir. Hippocampal mossy fibers exhibit weak enkephalin and strong dynorphin immunostaining. Intrahippocampal colchicine injections, which selectively destroy dentate granule cells, reduce enkephalin-ir and dynorphin-ir in mossy fibers. Intraventricular kainic acid, which causes degeneration of CA3-4 pyramidal cells, results in increased enkephalin immunostaining in mossy fibers. The enkephalin-ir cells and fibers of the entorhinal cortex which innervate the hippocampus and dentate gyrus do not contain dynorphin-ir.

subject areas

  • Animals
  • Cross Reactions
  • Endorphins
  • Enkephalins
  • Hippocampus
  • Histocytochemistry
  • Immunologic Techniques
  • Radioimmunoassay
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(82)90213-2

PubMed ID

  • 6759828
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Additional Document Info

start page

  • 1797

end page

  • 1800

volume

  • 31

issue

  • 16-1

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