Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Relation between previous lipid-lowering therapy and infaret size (creatine kinase-mb level) in patients presenting with acute myocardial infarction

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Aronow, H. D.
  • Lincoff, A. M.
  • Quinn, M. J.
  • McRae, A. T.
  • Gurm, H. S.
  • Houghtaling, P. L.
  • Granger, C. B.
  • Harrington, R. A.
  • de Werf, F. V.
  • Topol, Eric
  • Lauer, M. S.
  • Gusto, Ilb

publication date

  • November 2008

journal

  • American Journal of Cardiology  Journal

abstract

  • Animal experimental data have shown that lipid-lowering agents reduce myocardial infarct size. This association has not been well studied in humans. We compared infarct size in 10,548 patients in the GUSTO IIb and PURSUIT trials who were (n = 1,028) or were not (n = 9,520) on lipid-lowering therapy before an enrolling myocardial infarction (MI). Patients using lipid-lowering agents before their index MI had smaller infarcts than those who were not using these agents (median peak creatine kinase [CK]-MB 4.2 vs 5.2 times the upper limit of normal [ULN]; p <0.0001). Similarly, in an unadjusted model, patients on previous lipid-lowering therapy were less likely to have a peak CK-MB >3 times the ULN (620 of 1,028 [60.3%] vs 6,486 of 9,520 patients [68.1%]; p <0.001; relative risk 0.88, 95% confidence interval 0.84 to 0.93, p <0.0001). In a covariate- and propensity-adjusted multivariable model, the association between pretreatment with lipid-lowering agents and smaller infarct size persisted (relative risk for CK-MB >3 times the ULN 0.94, 95% confidence interval 0.88 to 0.99, p = 0.04). In conclusion, patients on lipid-lowering agents before an MI had significantly smaller infarcts. These findings suggest that lipid-lowering therapy may exert additional salutary effects in the setting of acute coronary syndromes.

subject areas

  • Acute Coronary Syndrome
  • Aged
  • Cholesterol
  • Creatine Kinase, MB Form
  • Electrocardiography
  • Female
  • Humans
  • Hyperlipidemias
  • Hypolipidemic Agents
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Myocytes, Cardiac
  • Necrosis
  • Risk Factors
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2008.06.032

PubMed ID

  • 18940276
scroll to property group menus

Additional Document Info

start page

  • 1119

end page

  • 1124

volume

  • 102

issue

  • 9

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support