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Pregnane steroid alphaxalone attenuates anxiogenic behavioral-effects of corticotropin releasing-factor and stress

Academic Article
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Overview

authors

  • Britton, K. T.
  • McLeod, S.
  • Koob, George
  • Hauger, R.

publication date

  • February 1992

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The 3 alpha-hydroxy A-ring-reduced steroid alphaxalone was examined for its ability to block stress-induced behavioral effects. Alphaxalone (3 and 6 mg/kg, IP) significantly antagonized the response-suppressing effects of corticotropin releasing factor (CRF) (0.5 micrograms, ICV) on punished responding in a conflict paradigm. In the plus maze, alphaxalone (3 and 6 mg/kg, IP) blocked the anxiogenic behavioral effects produced by a prior ambient-temperature swim stress. These doses of alphaxalone produced no intrinsic effects on plasma ACTH levels, nor did they attenuate CRF-induced increases in plasma ACTH. These findings support the hypothesis that some pregnane steroids may be involved in the modulation of an animal's behavioral response to stress and suggest that these effects may occur independently of the hypothalamic-pituitary-adrenocortical axis.

subject areas

  • Adrenocorticotropic Hormone
  • Animals
  • Anxiety
  • Corticotropin-Releasing Hormone
  • Male
  • Motor Activity
  • Pregnanediones
  • Rats
  • Rats, Inbred Strains
  • Reinforcement Schedule
  • Steroids
  • Stress, Physiological
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Research

keywords

  • ALPHAXALONE
  • CONFLICT
  • CORTICOTROPIN RELEASING FACTOR
  • PLUS MAZE
  • STEROIDS
  • STRESS
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(92)90117-x

PubMed ID

  • 1315440
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Additional Document Info

start page

  • 399

end page

  • 403

volume

  • 41

issue

  • 2

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