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Dopamine d-1 receptors are involved in the modulation of d-2 receptors induced by cholecystokinin receptor subtypes in rat neostriatal membranes

Academic Article
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Overview

authors

  • Li, X. M.
  • Hedlund, Peter
  • Agnati, L. F.
  • Fuxe, K.

publication date

  • July 1994

journal

  • Brain Research  Journal

abstract

  • The action of cholecystokinin octapeptide (CCK-8) on rat neostriatal dopamine (DA) D2 receptors was evaluated in membrane binding experiments. 0.1 nM of CCK-8 increased the Kd value of the D2 agonist [3H]N-propylnorapomorphine (NPA) binding sites by 42%. The CCKB antagonist PD134308 blocked this action. Kinetic analysis demonstrated that this effect of CCK-8 was related to a reduction by 45% of the association rate constant of [3H]NPA. In contrast, 1 nM of CCK-8 decreased the KH and the KL values of DA for the D2 antagonist [3H]raclopride binding sites by 56% and 50%, respectively. Both the CCKA antagonist L364718 and the CCKB antagonist PD134308 blocked this effect. The D1 antagonist SCH23390 counteracted the CCK-8 induced decrease in the KH and the KL values of DA, and allowed 1 nM of CCK-8 to produce a significant increase in the IC50 value of NPA for the [3H]raclopride binding sites. These results indicate that CCK-8 can reduce the affinity of the neostriatal D2 agonist binding sites, but increase the affinity of D2 receptors for DA. D1 receptors may exert a switching role in the modulation of the neostriatal D2 receptors by the CCK receptors.

subject areas

  • Animals
  • Apomorphine
  • Benzazepines
  • Binding, Competitive
  • Dopamine
  • Dopamine Agonists
  • In Vitro Techniques
  • Kinetics
  • Male
  • Membranes
  • Neostriatum
  • Raclopride
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cholecystokinin
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Salicylamides
  • Sincalide
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Research

keywords

  • CHOLECYSTOKININ RECEPTOR
  • DOPAMINE RECEPTOR
  • RAT NEOSTRIATAL MEMBRANE
  • RECEPTOR-RECEPTOR INTERACTIONS
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(94)91794-9

PubMed ID

  • 7953694
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Additional Document Info

start page

  • 289

end page

  • 298

volume

  • 650

issue

  • 2

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