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Broadening the aldolase catalytic antibody repertoire by combining reactive immunization and transition state theory: New enantio- and diastereoselectivities

Academic Article
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Overview

authors

  • Zhong, Guo-Fu
  • Lerner, Richard
  • Barbas III, Carlos

publication date

  • 1999

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • Nine efficient aldolase antibodies were generated by using hapten 1. This hapten unites reactive immunization and the transition state analogue approach in a single molecule. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereoselectivities opposite to that of antibody 38C2.
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Research

keywords

  • aldol reactions
  • asymmetric synthesis
  • catalytic antibodies
  • enantiomeric resolution
  • retro reactions
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/(sici)1521-3773(19991216)38:24<3738::aid-anie3738>3.0.co;2-2

PubMed ID

  • 10649343
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Additional Document Info

start page

  • 3738

end page

  • 3741

volume

  • 38

issue

  • 24

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