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Redefining risk in acute coronary syndromes using molecular medicine

Academic Article
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Overview

authors

  • Anwaruddin, S.
  • Askari, A. T.
  • Topol, Eric

publication date

  • January 2007

journal

  • Journal of the American College of Cardiology  Journal

abstract

  • Acute coronary syndromes represent a complex phenotype involving the interplay of many elements. The risk of developing an acute coronary syndrome and related complications has been defined by variables such as age, diabetes, smoking history, serum creatine phosphokinase, or electrocardiographic findings. However, in the past 5 years the wide-scale acceptance of a protein--troponin--has changed the diagnostic profile. With advances in molecular medicine, this protein is a segue to a panel of molecular assays that will improve screening and tailored intervention. We expound upon some of these factors and the potential they may carry in changing clinical medicine.

subject areas

  • Angina, Unstable
  • C-Reactive Protein
  • CD40 Ligand
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Molecular Biology
  • Myocardial Infarction
  • Myocardial Revascularization
  • P-Selectin
  • Prognosis
  • Risk Assessment
  • Sensitivity and Specificity
  • Troponin T
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Identity

International Standard Serial Number (ISSN)

  • 0735-1097

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2006.08.051

PubMed ID

  • 17239708
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Additional Document Info

start page

  • 279

end page

  • 289

volume

  • 49

issue

  • 3

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