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A second-generation copper(II)-mediated metallo-DNA-base pair

Academic Article
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Overview

authors

  • Zimmermann, N.
  • Meggers, E.
  • Schultz, Peter

publication date

  • February 2004

journal

  • Bioorganic Chemistry  Journal

abstract

  • Metal-dependent pairing of nucleobases represents an alternative DNA base pairing scheme. Our first-generation copper(II)-mediated pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) metallo-base pair has a stability comparable to the natural base pairs dA:dT and dC:dG but does not have the selectivity of the Watson Crick base pairs. In order to increase the selectivity of base pair formation, a second-generation metallo-base pair was generated consisting of a pyridine-2,6-dicarboxamide (Dipam) and a pyridine (Py) nucleobase. This new metallo-base pair is more stable than the natural base pairs dA:dT and dC:dG and highly selective against mispairing. In addition, incorporation of multiple metallo-base pairs into DNA results in the formation of stable duplexes demonstrating that hydrogen bonding base pairs can efficiently be replaced by metal-dependent base pairs at multiple sites in DNA.

subject areas

  • Base Pairing
  • Copper
  • DNA
  • Ligands
  • Nucleic Acid Conformation
  • Nucleosides
  • Organometallic Compounds
  • Organophosphorus Compounds
  • Picolinic Acids
  • Pyridines
  • Temperature
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Research

keywords

  • alternative binding schemes
  • copper(II)
  • metallo-DNA-base pairs
  • nucleobases
  • tridentate pyridine ligands
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Identity

International Standard Serial Number (ISSN)

  • 0045-2068

Digital Object Identifier (DOI)

  • 10.1016/j.bioorg.2003.09.001

PubMed ID

  • 14700559
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Additional Document Info

start page

  • 13

end page

  • 25

volume

  • 32

issue

  • 1

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