recent publications

• academic article

  • Wang, R. E., Liu, T., Wang, Y., Cao, Y., Du, J., Luo, X., Deshmukh, V., Kim, C. H., Lawson, B. R., Tremblay, M. S., Young, T. S., Kazane, S. A., et al. An immunosuppressive antibody-drug conjugate Journal of the American Chemical Society  2015 137:3229-3232  DOI:10.1021/jacs.5b00620  PMID:25699419  PMCID:PMC4472444
  • Harbut, M. B., Vilcheze, C., Luo, X., Hensler, M. E., Guo, H., Yang, B., Chatterjee, A. K., Nizet, V., Jacobs Jr., W. R., Schultz, P. G., Wang, F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis Proceedings of the National Academy of Sciences of the United States of America  2015 112:4453-4458  DOI:10.1073/pnas.1504022112  PMID:25831516  PMCID:PMC4394260
  • Liu, T., Zhang, Y., Liu, Y., Wang, Y., Jia, H., Kang, M., Luo, X., Caballero, D., Gonzalez, J., Sherwood, L., Nunez, V., Wang, D., et al. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists Proceedings of the National Academy of Sciences of the United States of America  2015 112:1356-1361  DOI:10.1073/pnas.1423668112  PMID:25605877  PMCID:PMC4321239
  • Xu, K., Ma, L., Li, Y., Wang, F., Zheng, G. Y., Sun, Z., Jiang, F., Chen, Y., Liu, H., Dang, A., Chen, X., Chun, J., et al. Genetic and functional evidence supports LPAR1 as a susceptibility gene for hypertension Hypertension  2015 66:641-646  DOI:10.1161/hypertensionaha.115.05515  PMID:26123684
  • Liu, T., Fu, G., Luo, X., Liu, Y., Wang, Y., Wang, R. E., Schultz, P. G., Wang, F. Rational design of antibody protease inhibitors Journal of the American Chemical Society  2015 137:4042-4045  DOI:10.1021/ja5130786  PMID:25775396
  • Huang, Q., Chen, B., Wang, F., Huang, H., Milner, R., Li, L. The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia Restorative Neurology and Neuroscience  2015 33:493-507  DOI:10.3233/rnn-140491  PMID:26409408
  • Zhang, Y., Goswami, D., Wang, D., Wang, T. S. A., Sen, S., Magliery, T. J., Griffin, P. R., Wang, F., Schultz, P. G. An antibody with a variable-region coiled-coil "knob" domain Angewandte Chemie-International Edition  2014 53:132-135  DOI:10.1002/anie.201307939  PMID:24254636  PMCID:PMC3926434
  • Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science  2014 345:328-332  DOI:10.1126/science.1252943  PMID:25035493  PMCID:PMC4188629
  • Liu, T., Liu, Y., Wang, Y., Hull, M., Schultz, P. G., Wang, F. Rational design of CXCR4 specific antibodies with elongated CDRs Journal of the American Chemical Society  2014 136:10557-10560  DOI:10.1021/ja5042447  PMID:25041362  PMCID:PMC4120998
  • Zhou, J. J., Wang, F., Xu, Z., Lo, W. S., Lau, C. F., Chiang, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M., Schimmel, P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis Journal of Biological Chemistry  2014 289:19269-19275  DOI:10.1074/jbc.C114.571026  PMID:24898250  PMCID:PMC4094037
  • Zhang, Y., Wang, D. L., Welzel, G., Wang, Y., Schultz, P. G., Wang, F. An antibody CDR3-erythropoietin fusion protein ACS Chemical Biology  2013 8:2117-2121  DOI:10.1021/cb4004749  PMID:23941200  PMCID:PMC3800483
  • Zhang, Y., Wang, D. L., de Lichtervelde, L., Sun, S. B., Smider, V. V., Schultz, P. G., Wang, F. Functional antibody CDR3 fusion proteins with enhanced pharmacological properties Angewandte Chemie-International Edition  2013 52:8295-8298  DOI:10.1002/anie.201303656  PMID:23794517  PMCID:PMC3783209
  • Wang, F., Sambandan, D., Halder, R., Wang, J. N., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P. Y., Zhang, Y., Kim, J., Hassani, M., Huszar, S., et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis Proceedings of the National Academy of Sciences of the United States of America  2013 110:E2510-E2517  DOI:10.1073/pnas.1309171110  PMID:23776209  PMCID:PMC3703973
  • Sun, S. B., Sen, S., Kim, N. J., Magliery, T. J., Schultz, P. G., Wang, F. Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Journal of the American Chemical Society  2013 135:9980-9983  DOI:10.1021/ja402927u  PMID:23795814  PMCID:PMC3773045
  • Wang, F., Xu, Z., Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases Journal of Biological Chemistry  2013 288:29223-29228  DOI:10.1074/jbc.C113.490599  PMID:24003230  PMCID:PMC3795223
  • Wang, F., Ekiert, D. C., Ahmad, I., Yu, W., Zhang, Y., Bazirgan, O., Torkamani, A., Raudsepp, T., Mwangi, W., Criscitiello, M. F., Wilson, I. A., Schultz, P. G., et al. Reshaping antibody diversity Cell  2013 153:1379-1393  DOI:10.1016/j.cell.2013.04.049  PMID:23746848  PMCID:PMC4007204
  • Wang, F., Zhang, Z. H., Wang, X. H., Li, J. L., Zha, L., Yuan, C. G., Weissmann, C., Ma, J. Y. Genetic informational rna is not required for recombinant prion infectivity Journal of Virology  2012 86:1874-1876  DOI:10.1128/jvi.06216-11  PMID:22090130  PMCID:PMC3264365
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S., Wang, F., Lau, C. F., Wu, J. J., Nangle, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., et al. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing Structure  2012 20:1470-1477  DOI:10.1016/j.str.2012.08.001  PMID:22958643  PMCID:PMC3485694
  • Wang, F., Niu, W., Guo, J. T., Schultz, P. G. Unnatural amino acid mutagenesis of fluorescent proteins Angewandte Chemie-International Edition  2012 51:10132-10135  DOI:10.1002/anie.201204668  PMID:22951916
  • Groff, D., Wang, F., Jockusch, S., Turro, N. J., Schultz, P. G. A new strategy to photoactivate green fluorescent protein Angewandte Chemie-International Edition  2010 49:7677-7679  DOI:10.1002/anie.201003797  PMID:20836111  PMCID:PMC2953579
  • Wang, F., Robbins, S., Guo, J. T., Shen, W. J., Schultz, P. G. Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis PLoS One  2010 5:e9354  DOI:10.1371/journal.pone.0009354  PMID:20179771  PMCID:PMC2825273
  • Takuwa, N., Ohkura, S. I., Takashima, S. I., Ohtani, K., Okamoto, Y., Tanaka, T., Hirano, K., Usui, S., Wang, F., Du, W., Yoshioka, K., Banno, Y., et al. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovascular Research  2010 85:484-493  DOI:10.1093/cvr/cvp312  PMID:19755413  PMCID:PMC2802201
  • Lee, H. S., Spraggon, G., Schultz, P. G., Wang, F. Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe Journal of the American Chemical Society  2009 131:2481-2483  DOI:10.1021/ja808340b  PMID:19193005  PMCID:PMC2679636
  • Olivera, A., Rosenfeldt, H. M., Bektas, M., Wang, F., Ishii, I., Chun, J., Milstien, S., Spiegel, S. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors Journal of Biological Chemistry  2003 278:46452-46460  DOI:10.1074/jbc.M308749200  PMID:12963721