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B cell clonal elimination induced by membrane-bound self-antigen may require repeated antigen encounter or cell competition

Academic Article
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Overview

authors

  • Lang, J.
  • Nemazee, David

publication date

  • February 2000

journal

  • European Journal of Immunology  Journal

abstract

  • Transgenic mouse experiments indicate that autoreactive B cells are eliminated upon encounter with membrane self-antigen. In this study we tested how B cell tolerance to MHC class I antigens is affected by altering the frequency of antigen-carrying cells in mixed bone marrow (BM) chimeras. When antigen-bearing cells are present at low frequency, the reactive B cells and their antigens may coexist in the peripheral lymphoid organs, but under these conditions the B cells are functionally anergic and have a shortened lifespan. Such putative anergic cells are strongly deleted in the presence of additional, non-antigen-bearing, non-transgenic B cells. Since the antigen concentration on the surface of each antigen-bearing cell should be high, these results suggest that for efficient deletion of autoreactive B cells multiple antigen encounters may be required, particularly when cellular competition is weak. These results have implications for the therapeutic use of BM chimerism to induce B cell tolerance to grafts.

subject areas

  • Animals
  • Antigens, Surface
  • Autoantigens
  • B-Lymphocytes
  • Cell Differentiation
  • Dose-Response Relationship, Immunologic
  • Immune Tolerance
  • Lymphocyte Activation
  • Mice
  • Receptors, Antigen, B-Cell
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Research

keywords

  • B lymphocyte
  • anergy
  • antigen dose
  • immune tolerance
  • receptor editing
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/1521-4141(200002)30:2<689::aid-immu689>3.3.co;2-9

PubMed ID

  • 10671228
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Additional Document Info

start page

  • 689

end page

  • 696

volume

  • 30

issue

  • 2

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