Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Natural antibodies with the t15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Shaw, P. X.
  • Horkko, S.
  • Chang, M. K.
  • Curtiss, Linda
  • Palinski, W.
  • Silverman, G. J.
  • Witztum, J. L.

publication date

  • June 2000

journal

  • Journal of Clinical Investigation  Journal

abstract

  • The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic "natural" T15 anti-PC Abs that are of B-1 cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.

subject areas

  • Amino Acid Sequence
  • Animals
  • Apolipoproteins E
  • Apoptosis
  • Arteriosclerosis
  • Autoantibodies
  • B-Lymphocytes
  • Base Sequence
  • DNA Primers
  • Gene Rearrangement
  • Genes, Immunoglobulin
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Idiotypes
  • Immunoglobulin Light Chains
  • Immunoglobulin M
  • Lipoproteins, LDL
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Phospholipid Ethers
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci8472

PubMed ID

  • 10862788
scroll to property group menus

Additional Document Info

start page

  • 1731

end page

  • 1740

volume

  • 105

issue

  • 12

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support