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Growth-related alterations induced in chick embryo fibroblasts by src-gene deletion mutants of the schmidt-ruppin strain of rous sarcoma virus

Academic Article
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Overview

authors

  • Breitman, M. L.
  • Vigne, R.
  • Vogt, Peter K.

publication date

  • 1980

journal

  • Cold Spring Harbor Symposia on Quantitative Biology  Journal

abstract

  • Certain tdSRD viruses induce multilayered cell foci, agar colony formation, and increased density of cellular populations in line-15 chick embryo fibroblasts. These alterations in cellular growth properties are distinct from oncogenic transformation. Available evidence favors the idea that transformation-defective focus formation is caused by one or more of the replicative viral genes, but which of the three-gag, pol, or env-is involved, remains to be determined.

subject areas

  • Animals
  • Avian Sarcoma Viruses
  • Carrier Proteins
  • Cell Division
  • Cell Transformation, Viral
  • Chick Embryo
  • Chromosome Deletion
  • Cytoskeleton
  • Defective Viruses
  • Fibronectins
  • Genes, Viral
  • Hexoses
  • Mutation
  • Plasminogen Activators
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Identity

International Standard Serial Number (ISSN)

  • 0091-7451

PubMed ID

  • 6253179
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Additional Document Info

start page

  • 1047

end page

  • 1055

volume

  • 44

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