recent publications

• academic article

  • Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K. B., et al. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor Proceedings of the National Academy of Sciences of the United States of America  2013 110:15892-15897  DOI:10.1073/pnas.1315049110  PMID:24043811  PMCID:PMC3791779
  • Hirose, T., Sunazuka, T., Sugawara, A., Endo, A., Iguchi, K., Yamamoto, T., Ui, H., Shiomi, K., Watanabe, T., Sharpless, K. B., Omura, S. Chitinase inhibitors: Extraction of the active framework from natural argifin and use of in situ click chemistry Journal of Antibiotics  2009 62:277-282  DOI:10.1038/ja.2009.28  PMID:19329983
  • Sugawara, A., Sunazuka, T., Hirose, T., Nagai, K., Yamaguchi, Y., Hanaki, H., Sharpless, K. B., Omura, S. Design and synthesis via click chemistry of 8,9-anhydroerythromycin a 6,9-hemiketal analogues with anti-mrsa and -vre activity Bioorganic & Medicinal Chemistry Letters  2007 17:6340-6344  DOI:10.1016/j.bmcl.2007.08.068  PMID:17869508
  • Hirose, T., Sunazuka, T., Noguchi, Y., Yamaguchi, Y., Hanaki, H., Sharpless, K. B., Omura, S. Rapid 'SAR' via click chemistry: An alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates Heterocycles  2006 69:55-61  DOI:10.3987/COM-06-S(O)7