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Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys

Academic Article
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Overview

authors

  • Gold, L. H.
  • Fox, H. S.
  • Henriksen, S. J.
  • Buchmeier, M. J.
  • Weed, M. R.
  • Taffe, Michael
  • Huitron-Resendiz, S.
  • Horn, T. F. W.
  • Bloom, Floyd

publication date

  • April 1998

journal

  • Journal of Medical Primatology  Journal

abstract

  • A model is proposed in which a neurovirulent, microglial-passaged, simian immunodeficiency virus (SIV) is used to produce central nervous system (CNS) pathology and behavioral deficits in rhesus monkeys reminiscent of those seen in humans infected with human immunodeficiency virus (HIV). The time course of disease progression was characterized by using functional measures of cognition and motor skill, as well as neurophysiologic monitoring. Concomitant assessment of immunological and virological parameters illustrated correspondence between impaired behavioral performance and viral pathogenesis. Convergent results were obtained from neuropathological findings indicative of significant CNS disease. In ongoing studies, this SIV model is being used to explore the behavioral sequelae of immunodeficiency virus infection, the viral and host factors leading to neurologic dysfunction, and to begin testing potential therapeutic agents.

subject areas

  • Animals
  • Cognition
  • Disease Models, Animal
  • Disease Progression
  • HIV Infections
  • Humans
  • Longitudinal Studies
  • Macaca mulatta
  • Motor Activity
  • Neuropsychological Tests
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus
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Research

keywords

  • AIDS
  • CNS
  • dementia
  • immunodeficiency
  • macaque
  • neuropsychological
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Identity

International Standard Serial Number (ISSN)

  • 0047-2565

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0684.1998.tb00234.x

PubMed ID

  • 9747951
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Additional Document Info

start page

  • 104

end page

  • 112

volume

  • 27

issue

  • 2-3

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