recent publications

• academic article

  • Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Whitton, J. L. Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo Autophagy  2015 11:1389-1407  DOI:10.1080/15548627.2015.1063769  PMID:26090585  PMCID:PMC4590631
  • Marcondes, M. C. G., Morsey, B., Emanuel, K., Lamberty, B. G., Flynn, C. T., Fox, H. S. CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system Journal of Infectious Diseases  2015 211:40-44  DOI:10.1093/infdis/jiu401  PMID:25035516  PMCID:PMC4334822
  • Hosking, M. P., Flynn, C. T., Whitton, J. L. Antigen-specific naive CD8(+) T cells produce a single pulse of IFN-gamma in vivo within hours of infection, but without antiviral effect Journal of Immunology  2014 193:1873-1885  DOI:10.4049/jimmunol.1400348  PMID:25015828  PMCID:PMC4119517
  • Althof, N., Harkins, S., Kemball, C. C., Flynn, C. T., Alirezaei, M., Whitton, J. L. In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease Journal of Virology  2014 88:5087-5099  DOI:10.1128/jvi.00184-14  PMID:24574394  PMCID:PMC3993796
  • Hosking, M. P., Flynn, C. T., Botten, J., Whitton, J. L. CD8+ memory T cells appear exhausted within hours of acute virus infection Journal of Immunology  2013 191:4211-4222  DOI:10.4049/jimmunol.1300920  PMID:24026080  PMCID:PMC3795851
  • Kemball, C. C., Flynn, C. T., Hosking, M. P., Botten, J., Whitton, J. L. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo Virology  2012 429:74-90  DOI:10.1016/j.virol.2012.04.005  PMID:22551767  PMCID:PMC3358485
  • Alirezaei, M., Flynn, C. T., Whitton, J. L. Interactions between enteroviruses and autophagy in vivo Autophagy  2012 8:973-975  DOI:10.4161/auto.20160  PMID:22705981  PMCID:PMC3427263
  • Alirezaei, M., Flynn, C. T., Wood, M. R., Whitton, J. L. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo Cell Host & Microbe  2012 11:298-305  DOI:10.1016/j.chom.2012.01.014  PMID:22423969  PMCID:PMC3308121
  • Kemball, C. C., Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Kiosses, W. B., Whitton, J. L. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo Journal of Virology  2010 84:12110-12124  DOI:10.1128/jvi.01417-10  PMID:20861268  PMCID:PMC2976412
  • Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., Kiosses, W. B. Short-term fasting induces profound neuronal autophagy Autophagy  2010 6:702-710  DOI:10.4161/auto.6.6.12376  PMID:20534972  PMCID:PMC3106288
  • Kemball, C. C., Harkins, S., Whitmire, J. K., Flynn, C. T., Feuer, R., Whitton, J. L. Coxsackievirus b3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the mhc class i pathway PLoS Pathogens  2009 5:e1000618  DOI:10.1371/journal.ppat.1000618  PMID:19834548  PMCID:PMC2757675
  • Alirezaei, M., Fox, H. S., Flynn, C. T., Moore, C. S., Hebb, A. L. O., Frausto, R. F., Bhan, V., Kiosses, W. B., Whitton, J. L., Robertson, G. S., Crocker, S. J. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis Autophagy  2009 5:152-158  DOI:10.4161/auto.5.2.7348  PMID:19066443  PMCID:PMC2779564
  • Huitron-Resendiz, S., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M. S., Fox, H. S. Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity Proceedings of the National Academy of Sciences of the United States of America  2007 104:15138-15143  DOI:10.1073/pnas.0707171104  PMID:17846423  PMCID:PMC1986626
  • Roberts, E. S., Huitron-Rosendiz, S., Taffe, M. A., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M., Hammond, J. A., Head, S. R., Henriksen, S. J., Fox, H. S. Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection Journal of Neuroscience  2006 26:4577-4585  DOI:10.1523/jneurosci.4504-05.2006  PMID:16641237
  • Madden, L. J., Flynn, C. T., Zandonatti, M. A., May, M., Parsons, L. H., Katner, S. N., Henriksen, S. J., Fox, H. S. Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities Neuropsychopharmacology  2005 30:350-359  DOI:10.1038/sj.npp.1300575  PMID:15483561
  • Katner, S. N., Flynn, C. T., Von Huben, S. N., Kirsten, A. J., Davis, S. A., Lay, C. C., Cole, M., Roberts, A. J., Fox, H. S., Taffe, M. A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcoholism-Clinical and Experimental Research  2004 28:873-883  DOI:10.1097/01.alc.0000128895.99379.8c  PMID:15201630
  • Madden, L. J., Zandonatti, M. A., Flynn, C. T., Taffe, M. A., Marcondes, M. C. G., Schmitz, J. E., Reimann, K. A., Henriksen, S. J., Fox, H. S. CD8+ cell depletion amplifies the acute retroviral syndrome Journal of Neurovirology  2004 10:58-66  DOI:10.1080/13550280490268269  PMID:14982741