recent publications
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academic article
- Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Whitton, J. L. Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo Autophagy 2015 11:1389-1407 DOI:10.1080/15548627.2015.1063769 PMID:26090585 PMCID:PMC4590631
- Marcondes, M. C. G., Morsey, B., Emanuel, K., Lamberty, B. G., Flynn, C. T., Fox, H. S. CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system Journal of Infectious Diseases 2015 211:40-44 DOI:10.1093/infdis/jiu401 PMID:25035516 PMCID:PMC4334822
- Hosking, M. P., Flynn, C. T., Whitton, J. L. Antigen-specific naive CD8(+) T cells produce a single pulse of IFN-gamma in vivo within hours of infection, but without antiviral effect Journal of Immunology 2014 193:1873-1885 DOI:10.4049/jimmunol.1400348 PMID:25015828 PMCID:PMC4119517
- Althof, N., Harkins, S., Kemball, C. C., Flynn, C. T., Alirezaei, M., Whitton, J. L. In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease Journal of Virology 2014 88:5087-5099 DOI:10.1128/jvi.00184-14 PMID:24574394 PMCID:PMC3993796
- Hosking, M. P., Flynn, C. T., Botten, J., Whitton, J. L. CD8+ memory T cells appear exhausted within hours of acute virus infection Journal of Immunology 2013 191:4211-4222 DOI:10.4049/jimmunol.1300920 PMID:24026080 PMCID:PMC3795851
- Kemball, C. C., Flynn, C. T., Hosking, M. P., Botten, J., Whitton, J. L. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo Virology 2012 429:74-90 DOI:10.1016/j.virol.2012.04.005 PMID:22551767 PMCID:PMC3358485
- Alirezaei, M., Flynn, C. T., Whitton, J. L. Interactions between enteroviruses and autophagy in vivo Autophagy 2012 8:973-975 DOI:10.4161/auto.20160 PMID:22705981 PMCID:PMC3427263
- Alirezaei, M., Flynn, C. T., Wood, M. R., Whitton, J. L. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo Cell Host & Microbe 2012 11:298-305 DOI:10.1016/j.chom.2012.01.014 PMID:22423969 PMCID:PMC3308121
- Kemball, C. C., Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Kiosses, W. B., Whitton, J. L. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo Journal of Virology 2010 84:12110-12124 DOI:10.1128/jvi.01417-10 PMID:20861268 PMCID:PMC2976412
- Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., Kiosses, W. B. Short-term fasting induces profound neuronal autophagy Autophagy 2010 6:702-710 DOI:10.4161/auto.6.6.12376 PMID:20534972 PMCID:PMC3106288
- Kemball, C. C., Harkins, S., Whitmire, J. K., Flynn, C. T., Feuer, R., Whitton, J. L. Coxsackievirus b3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the mhc class i pathway PLoS Pathogens 2009 5:e1000618 DOI:10.1371/journal.ppat.1000618 PMID:19834548 PMCID:PMC2757675
- Alirezaei, M., Fox, H. S., Flynn, C. T., Moore, C. S., Hebb, A. L. O., Frausto, R. F., Bhan, V., Kiosses, W. B., Whitton, J. L., Robertson, G. S., Crocker, S. J. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis Autophagy 2009 5:152-158 DOI:10.4161/auto.5.2.7348 PMID:19066443 PMCID:PMC2779564
- Huitron-Resendiz, S., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M. S., Fox, H. S. Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity Proceedings of the National Academy of Sciences of the United States of America 2007 104:15138-15143 DOI:10.1073/pnas.0707171104 PMID:17846423 PMCID:PMC1986626
- Roberts, E. S., Huitron-Rosendiz, S., Taffe, M. A., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M., Hammond, J. A., Head, S. R., Henriksen, S. J., Fox, H. S. Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection Journal of Neuroscience 2006 26:4577-4585 DOI:10.1523/jneurosci.4504-05.2006 PMID:16641237
- Madden, L. J., Flynn, C. T., Zandonatti, M. A., May, M., Parsons, L. H., Katner, S. N., Henriksen, S. J., Fox, H. S. Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities Neuropsychopharmacology 2005 30:350-359 DOI:10.1038/sj.npp.1300575 PMID:15483561
- Katner, S. N., Flynn, C. T., Von Huben, S. N., Kirsten, A. J., Davis, S. A., Lay, C. C., Cole, M., Roberts, A. J., Fox, H. S., Taffe, M. A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcoholism-Clinical and Experimental Research 2004 28:873-883 DOI:10.1097/01.alc.0000128895.99379.8c PMID:15201630
- Madden, L. J., Zandonatti, M. A., Flynn, C. T., Taffe, M. A., Marcondes, M. C. G., Schmitz, J. E., Reimann, K. A., Henriksen, S. J., Fox, H. S. CD8+ cell depletion amplifies the acute retroviral syndrome Journal of Neurovirology 2004 10:58-66 DOI:10.1080/13550280490268269 PMID:14982741