An improved synthesis of alpha,beta-unsaturated nitrones relevant to the stephacidins and analogs thereof

Academic Article
uri icon

related to degree

publication date

  • July 2009

abstract

  • A new method is reported for the synthesis of the alpha,beta-unsaturated nitrone moiety characteristic of the stephacidin/avrainvillamide family of bioactive prenylated indole alkaloids. Application to the synthesis of stephacidin analogs and a potential biological probe are showcased.