An improved synthesis of alpha,beta-unsaturated nitrones relevant to the stephacidins and analogs thereof

Academic Article
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publication date

  • 2009

abstract

  • A new method is reported for the synthesis of the alpha,beta-unsaturated nitrone moiety characteristic of the stephacidin/avrainvillamide family of bioactive prenylated indole alkaloids. Application to the synthesis of stephacidin analogs and a potential biological probe are showcased.