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Mice expressing activated camkii lack low frequency ltp and do not form stable place cells in the ca1 region of the hippocampus

Academic Article
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Overview

authors

  • Rotenberg, A.
  • Mayford, Mark
  • Hawkins, R. D.
  • Kandel, E. R.
  • Muller, R. U.

publication date

  • December 1996

journal

  • Cell  Journal

abstract

  • To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they lack LTP in response to stimulation at 5-10 Hz and are impaired on spatial memory tasks. In these transgenic mice, the place cells in the CA1 region have three important differences from those of wild types: they are less common, less precise, and less stable. These findings suggest that LTP in the 5-10 Hz range may be important for the maintenance of place-field stability and that this stability may be essential for the storage of spatial memory.

subject areas

  • Action Potentials
  • Animals
  • Behavior, Animal
  • Brain Mapping
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cognition
  • Hippocampus
  • Long-Term Potentiation
  • Memory
  • Mice
  • Mice, Transgenic
  • Neuronal Plasticity
  • Space Perception
  • Synapses
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81829-2

PubMed ID

  • 8980240
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Additional Document Info

start page

  • 1351

end page

  • 1361

volume

  • 87

issue

  • 7

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