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Enediyne natural products: Biosynthesis and prospect towards engineering novel antitumor agents

Academic Article
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Overview

authors

  • Shen, Ben
  • Liu, W.
  • Nonaka, K.

publication date

  • November 2003

journal

  • Current Medicinal Chemistry  Journal

abstract

  • This review gives a brief account on the current status of enediyne biosynthesis and the prospective of applying combinatorial biosynthesis methods to the enediyne system for novel analog production. Methods for cloning enediyne biosynthetic gene clusters are first reviewed. A unified paradigm for enediyne biosynthesis, characterized with (a) the enediyne PKS, (b) the enediyne PKS accessory enzymes, and (c) tailoring enzymes, is then presented. Strategies and tools for novel enediyne analog production by combinatorial biosynthesis are finally discussed. The results set the stage to decipher the molecular mechanism for enediyne biosynthesis and lay the foundation to engineer novel enediynes by combinatorial biosynthesis for future endeavors.

subject areas

  • Antineoplastic Agents
  • Biological Products
  • Cloning, Molecular
  • Combinatorial Chemistry Techniques
  • Genetic Engineering
  • Molecular Probes
  • Multigene Family
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Research

keywords

  • C-1027
  • biosynthesis
  • calicheamicin
  • combinatorial biosynthesis
  • enediyne
  • polyketide synthase
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Identity

International Standard Serial Number (ISSN)

  • 0929-8673

Digital Object Identifier (DOI)

  • 10.2174/0929867033456701

PubMed ID

  • 14529344
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Additional Document Info

start page

  • 2317

end page

  • 2325

volume

  • 10

issue

  • 21

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