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Recognition and transport of adenine derivatives with synthetic receptors

Academic Article
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Overview

authors

  • Benzing, T.
  • Tjivikua, T.
  • Wolfe, J.
  • Rebek Jr., Julius

publication date

  • 1988

journal

  • Science  Journal

abstract

  • Several new synthetic agents show high affinity for binding adenine derivatives. The structures feature complementary hydrogen bonds that cause the molecular chelation of the purine nucleus. The high lipophilicity of the new agents permits the transport of adenosine and deoxyadenosine across organic liquid membranes. The use of synthetic receptors for small biological targets may have application in drug delivery.

subject areas

  • Adenine
  • Biological Transport
  • Chloroform
  • Deoxyadenosines
  • Drug Carriers
  • Hydrogen Bonding
  • Kinetics
  • Membranes, Artificial
  • Molecular Structure
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3262924

PubMed ID

  • 3262924
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Additional Document Info

start page

  • 266

end page

  • 268

volume

  • 242

issue

  • 4876

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