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Erythronolides h and i, new erythromycin congeners from a new halophilic actinomycete actinopolyspora sp yim90600

Academic Article
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Overview

authors

  • Huang, S. X.
  • Zhao, L. X.
  • Tang, S. K.
  • Jiang, C. L.
  • Duan, Y. W.
  • Shen, Ben

publication date

  • March 2009

journal

  • Organic Letters  Journal

abstract

  • Erythronolides H and I, novel congeners of the clinically important antibacterial drug erythromycin A, have been isolated from the new halophilic actinomycete Actinopolyspora sp. YIM90600. In addition to producing the new erythromycin congeners, A. sp. YIM90600 produces erythromycin C in a high titer. The presence of the C-14 hydroxyl moiety and the C-6/C-18-epoxide in erythronolide H and the spiroketal moiety of erythronolide I sheds new insights into structural diversity of erythromycin analog libraries potentially accessible by combinatorial biosynthesis.

subject areas

  • Actinomycetales
  • Anti-Bacterial Agents
  • Erythromycin
  • Molecular Structure
  • Stereoisomerism
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Identity

PubMed Central ID

  • PMC4123550

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol900143j

PubMed ID

  • 19228040
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Additional Document Info

start page

  • 1353

end page

  • 1356

volume

  • 11

issue

  • 6

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