recent publications

• academic article

  • Hsu, C. H., Schelwies, M., Enck, S., Huang, L. Y., Huang, S. H., Chang, Y. F., Cheng, T. J. R., Cheng, W. C., Wong, C. H. Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-Phosphate: synthesis and bacterial transglycosylase inhibition Journal of Organic Chemistry  2014 79:8629-8637  DOI:10.1021/jo501340s  PMID:25137529  PMCID:PMC4168788
  • Huang, C. Y., Shih, H. W., Lin, L. Y., Tien, Y. W., Cheng, T. J. R., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism Proceedings of the National Academy of Sciences of the United States of America  2012 109:6496-6501  DOI:10.1073/pnas.1203900109  PMID:22493270  PMCID:PMC3340074
  • Cheng, T. J. R., Weinheimer, S., Tarbet, E. B., Jan, J. T., Cheng, Y. S. E., Shie, J. J., Chen, C. L., Chen, C. A., Hsieh, W. C., Huang, P. W., Lin, W. H., Wang, S. Y., et al. Development of oseltamivir phosphonate congeners as anti-influenza agents Journal of Medicinal Chemistry  2012 55:8657-8670  DOI:10.1021/jm3008486  PMID:23009169  PMCID:PMC3492761
  • Shih, H. W., Chang, Y. F., Li, W. J., Meng, F. C., Huang, C. Y., Ma, C., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Effect of the peptide moiety of lipid ii on bacterial transglycosylase Angewandte Chemie-International Edition  2012 51:10123-10126  DOI:10.1002/anie.201204038  PMID:22952114
  • Liu, K. C., Fang, J. M., Jan, J. T., Cheng, T. J. R., Wang, S. Y., Yang, S. T., Cheng, Y. S. E., Wong, C. H. Enhanced anti-influenza agents conjugated with anti-inflammatory activity Journal of Medicinal Chemistry  2012 55:8493-8501  DOI:10.1021/jm3009844  PMID:22963087
  • Shih, H. W., Chen, K. T., Cheng, T. J. R., Wong, C. H., Cheng, W. C. A new synthetic approach toward bacterial transglycosylase substrates, lipid ii and lipid iv Organic Letters  2011 13:4600-4603  DOI:10.1021/ol201806d  PMID:21797279
  • Chen, M. W., Liao, H. Y., Huang, Y. X., Jan, J. T., Huang, C. C., Ren, C. T., Wu, C. Y., Cheng, T. J. R., Ho, D. D., Wong, C. H. Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Proceedings of the National Academy of Sciences of the United States of America  2011 108:3510-3515  DOI:10.1073/pnas.1019744108  PMID:21321237  PMCID:PMC3048126
  • Meng, F. C., Chen, K. T., Huang, L. Y., Shih, H. W., Chang, H. H., Nien, F. Y., Liang, P. H., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Total synthesis of polyprenyl n-glycolyl lipid ii as a mycobacterial transglycosylase substrate Organic Letters  2011 13:5306-5309  DOI:10.1021/ol2021687  PMID:21913698
  • Shih, H. W., Chen, K. T., Chen, S. K., Huang, C. Y., Cheng, T. J. R., Ma, C., Wong, C. H., Cheng, W. C. Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors Organic & Biomolecular Chemistry  2010 8:2586-2593  DOI:10.1039/c000622j  PMID:20485795
  • Liao, H. Y., Hsu, C. H., Wang, S. C., Liang, C. H., Yen, H. Y., Su, C. Y., Chen, C. H., Jan, J. T., Ren, C. T., Cheng, T. J. R., Wu, C. Y., Wong, C. H. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays Journal of the American Chemical Society  2010 132:14849-14856  DOI:10.1021/ja104657b  PMID:20882975
  • Cheng, T. J. R., Wu, Y. T., Yang, S. T., Lo, K. H., Chen, S. K., Chen, Y. H., Huang, W. I., Yuan, C. H., Guo, C. W., Huang, L. Y., Chen, K. T., Shih, H. W., et al. High-throughput identification of antibacterials against methicillin-resistant staphylococcus aureus (mrsa) and the transglycosylase Bioorganic & Medicinal Chemistry  2010 18:8512-8529  DOI:10.1016/j.bmc.2010.10.036  PMID:21075637
  • Su, C. Y., Cheng, T. J. R., Lin, M. I., Wang, S. Y., Huang, W. I., Lin-Chu, S. Y., Chen, Y. H., Wu, C. Y., Lai, M. M. C., Cheng, W. C., Wu, Y. T., Tsai, M. D., et al. High-throughput identification of compounds targeting influenza rna-dependent rna polymerase activity Proceedings of the National Academy of Sciences of the United States of America  2010 107:19151-19156  DOI:10.1073/pnas.1013592107  PMID:20974907  PMCID:PMC2984200
  • Shie, J. J., Chen, C. A., Lin, C. C., Ku, A. F., Cheng, T. J. R., Fang, J. M., Wong, C. H. Regioselective synthesis of di-c-glycosylflavones possessing anti-inflammation activities Organic & Biomolecular Chemistry  2010 8:4451-4462  DOI:10.1039/c0ob00011f  PMID:20725659
  • Liu, C. Y., Guo, C. W., Chang, Y. F., Wang, J. T., Shih, H. W., Hsu, Y. F., Chen, C. W., Chen, S. K., Wang, Y. C., Cheng, T. J. R., Ma, C., Wong, C. H., et al. Synthesis and evaluation of a new fluorescent transglycosylase substrate: Lipid ii-based molecule possessing a dansyl-c20 polyprenyl moiety Organic Letters  2010 12:1608-1611  DOI:10.1021/ol100338v  PMID:20187630
  • Wang, S. Y., Su, C. Y., Lin, M. G., Huang, S. Y., Huang, W. I., Wang, C. C., Wu, Y. T., Cheng, T. J. R., Yu, H. M., Ren, C. T., Wu, C. Y., Wong, C. H., et al. Ha-pseudotyped retroviral vectors for influenza antagonist screening Journal of Biomolecular Screening  2009 14:294-302  DOI:10.1177/1087057108330786  PMID:19211776
  • Chen, M. W., Cheng, T. J. R., Huang, Y. X., Jan, J. T., Ma, S. H., Yu, A. L., Wong, C. H., Ho, D. D. A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses Proceedings of the National Academy of Sciences of the United States of America  2008 105:13538-13543  DOI:10.1073/pnas.0806901105  PMID:18765801  PMCID:PMC2533225
  • Cheng, T. J. R., Sung, M. T., Liao, H. Y., Chang, Y. F., Chen, C. W., Huang, C. Y., Chou, L. Y., Wu, Y. D., Chen, Y., Cheng, Y. S. E., Wong, C. H., Ma, C., et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics Proceedings of the National Academy of Sciences of the United States of America  2008 105:431-436  DOI:10.1073/pnas.0710868105  PMID:18182485  PMCID:PMC2206553
  • Hsieh, Y. S. Y., Chien, C., Liao, S. K. S., Liao, S. F., Hung, W. T., Yang, W. B., Lin, C. C., Cheng, T. J. R., Chang, C. C., Fang, J. M., Wong, C. H. Structure and bioactivity of the polysaccharides in medicinal plant dendrobium huoshanense Bioorganic & Medicinal Chemistry  2008 16:6054-6068  DOI:10.1016/j.bmc.2008.04.042  PMID:18467102