Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Atm deficiency affects both apoptosis and proliferation to augment myc-induced lymphomagenesis

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Maclean, K. H.
  • Kastan, M. B.
  • Cleveland, John

publication date

  • July 2007

journal

  • Molecular Cancer Research  Journal

abstract

  • Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of cancer. However, the critical mechanisms by which Myc contributes to malignant transformation are not clear. DNA damage seems to be an important initiating event in tumorigenesis. Here, we show that although Myc does not directly induce double-stranded DNA breaks, it does augment activation of the Atm/p53 DNA damage response pathway, suggesting that Atm may function as a guardian against Myc-induced transformation. Indeed, we show that Atm loss augments Myc-induced lymphomagenesis and impairs Myc-induced apoptosis, which normally harnesses Myc-driven tumorigenesis. Surprisingly, Atm loss also augments the proliferative response induced by Myc, and this augmentation is associated with enhanced suppression of the expression of the cyclin-dependent kinase inhibitor p27(Kip1). Therefore, regulation of cell proliferation and p27(Kip1) seems to be a contributing mechanism by which Atm holds tumor formation in check.

subject areas

  • Animals
  • Apoptosis
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins
  • Cell Proliferation
  • DNA Damage
  • DNA-Binding Proteins
  • Fibroblasts
  • Humans
  • Lymphoma
  • Mice
  • Phosphorylation
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-myc
  • Radiation, Ionizing
  • Signal Transduction
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1541-7786

Digital Object Identifier (DOI)

  • 10.1158/1541-7786.mcr-07-0058

PubMed ID

  • 17634425
scroll to property group menus

Additional Document Info

start page

  • 705

end page

  • 711

volume

  • 5

issue

  • 7

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support