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Vitamin B-2-mediated cellular photoinhibition of botulinum neurotoxin A

Academic Article
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Overview

authors

  • Eubanks, L. M.
  • Dickerson, Tobin
  • Janda, Kim

publication date

  • October 2005

journal

  • FEBS Letters  Journal

abstract

  • Botulinum neurotoxin (BoNT) is the most toxic species known to humans and has been identified as a potential bioterrorist threat. Unfortunately, the only existing countermeasures for BoNT intoxication involve vaccinations that are only effective prior to entry of the toxin into neuronal cells. Herein, we disclose the ability of the micronutrient riboflavin (vitamin B(2)) to photooxidatively inactivate BoNT in cell-based assays without the need for toxin and riboflavin pre-exposure. In total, this study suggests that botulism neurotoxicity may be blunted with photodynamic therapy technology.

subject areas

  • Animals
  • Bioterrorism
  • Botulinum Toxins, Type A
  • PC12 Cells
  • Photochemistry
  • Rats
  • Riboflavin
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Research

keywords

  • bioterrorism
  • botulinum neurotoxin
  • photodynamic therapy
  • riboflavin
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Identity

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2005.08.072

PubMed ID

  • 16198354
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Additional Document Info

start page

  • 5361

end page

  • 5364

volume

  • 579

issue

  • 24

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