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Lethal escherichia-coli septic shock is prevented by blocking tissue factor with monoclonal-antibody

Academic Article
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Overview

authors

  • Taylor, F. B.
  • Chang, A.
  • Ruf, Wolfram
  • Morrissey, J. H.
  • Hinshaw, L.
  • Catlett, R.
  • Blick, K.
  • Edgington, Thomas

publication date

  • March 1991

journal

  • Circulatory Shock  Journal

abstract

  • Gram-negative bacteremia poses a major health problem, causing one-half of cases of lethal septic shock acquired during hospitalization. Bacterial lipopolysaccharide (LPS) and the inflammatory cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), have been shown to be essential mediators of septic shock. Among the effects of these mediators is a coagulopathy that may be triggered by induced expression of tissue factor (TF) on macrophages and endothelial cells. We now report that 500 micrograms/kg of either immunoglobulin G (IgG) or Fab fragments of a monoclonal antibody against TF administered to baboons as a pretreatment attenuates the coagulopathy and protects against LD100 Escherichia coli. This study provides direct evidence of an essential effector role for TF in septic shock.

subject areas

  • Adrenal Glands
  • Animals
  • Antibodies, Monoclonal
  • Blood Pressure
  • Creatinine
  • Escherichia coli Infections
  • Factor VII
  • Fibrinogen
  • Kidney
  • Liver
  • Lung
  • Papio
  • Shock, Septic
  • Spleen
  • Thromboplastin
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Research

keywords

  • BABOONS
  • CARDIOVASCULAR SHOCK
  • CELL INJURY
  • DISSEMINATED INTRAVASCULAR COAGULATION (DIC)
  • GRAM-NEGATIVE BACTEREMIA
  • INFLAMMATION
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Identity

International Standard Serial Number (ISSN)

  • 0092-6213

PubMed ID

  • 2044206
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Additional Document Info

start page

  • 127

end page

  • 134

volume

  • 33

issue

  • 3

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