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Cyclic GMP efflux from liver slices

Academic Article
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Overview

authors

  • Tjornhammar, M. L.
  • Lazaridis, G.
  • Bartfai, Tamas

publication date

  • 1983

journal

  • Journal of Biological Chemistry  Journal

abstract

  • Cyclic GMP efflux from liver slices was studied when the intracellular cyclic GMP levels were elevated by incubation with N-methyl-N'-nitro-N-nitrosoguanidine (0.1 mM) and 3-isobutyl-1-methylxanthine (0.25 mM). A probenecid-sensitive and a probenecid-insensitive efflux system for cyclic GMP was found. It is suggested that the former system operates a carrier, which is saturable, the capacity of which is increased by alkylation with N-ethylmaleimide. The rate of net efflux of cyclic GMP increases 20-fold in the temperature interval 18-37 degrees C. Probenecid (0.5 mM) gives 50% inhibition of this system. The probenecid-insensitive cyclic GMP efflux component probably corresponds to passive diffusion. It appears that efflux may be an important complement to cyclic 3':5'-nucleotide phosphodiesterase activity in reducing intracellular cyclic GMP levels.

subject areas

  • 1-Methyl-3-isobutylxanthine
  • Animals
  • Calcimycin
  • Calcium
  • Cyclic GMP
  • In Vitro Techniques
  • Iodoacetamide
  • Kinetics
  • Liver
  • Male
  • Methylnitronitrosoguanidine
  • Probenecid
  • Rats
  • Rats, Inbred Strains
  • Theophylline
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

PubMed ID

  • 6189831
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Additional Document Info

start page

  • 6882

end page

  • 6886

volume

  • 258

issue

  • 11

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