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Circulating immune-complexes in takayasu disease

Academic Article
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Overview

authors

  • Numano, F.
  • Maezawa, H.
  • Sawada, S.
  • Talal, N.
  • Theofilopoulos, Argyrios

publication date

  • 1980

journal

  • Japanese Circulation Journal-English Edition  Journal

abstract

  • Circulating immune complexes in Takayasu disease were investigated to assess the involvement of autoimmune mechanisms. Antibody dependent cell-mediated cytotoxicity (ADCC) and Raji cell assay revealed: The 10 percent inhibition of ADCC in 37 patients was 35.6 +/- 5.2, this being a non-statistically significant value as compared with the values of 25.6 +/- 3.0 in 33 apparently healthy controls. Raji cell assay values were 30.4 +/- 11.5 and 3.5 +/- 2.3 for patients and controls, respectively. As 54% of all these patients had a negative reaction and there was no correlation between immune complex levels and BSR, CRP, or ASO, immune complexes, while accelerating or modifying the pathophysiological state, probably are not primary causative factors.

subject areas

  • Adult
  • Antibody-Dependent Cell Cytotoxicity
  • Antigen-Antibody Complex
  • Antistreptolysin
  • Aortic Arch Syndromes
  • Autoimmune Diseases
  • Blood Sedimentation
  • C-Reactive Protein
  • Female
  • Genes, MHC Class II
  • Humans
  • Male
  • Takayasu Arteritis
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Identity

International Standard Serial Number (ISSN)

  • 0047-1828

PubMed ID

  • 6107391
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Additional Document Info

start page

  • 777

end page

  • 782

volume

  • 44

issue

  • 10

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