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Formation of antibody in the newborn mouse: study of T-cell-independent antibody response

Academic Article
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Overview

authors

  • Mosier, Donald
  • Zaldivar, N. M.
  • Goldings, E.
  • Mond, J.
  • Scher, I.
  • Paul, W. E.

publication date

  • 1977

journal

  • Journal of Infectious Diseases  Journal

abstract

  • The ontogeny of immune responsiveness, as assayed by antibody formation in vitro, of mouse spleen lymphocytes to thymus-independent antigens is reviewed. Responsiveness to trinitrophenyl (TNP)-lipopolysaccharide and TNP-Brucella abortus appear soon after birth and one to two weeks before TNP-Ficoll or capsular polysaccharide of Streptococcus pneumoniae (SSS-III) elicits significant antibody formation. This hierarchy of responsiveness to antigens is also apparent in the CBA/N mutant mouse strain, which has a bone marrow-derived (B-) cell maturation arrest and fails to respond to either TNP-ficoll or SSS-III. These findings are interpreted to suggest sequential maturation of different populations or lines of B-lymphocytes, each of which can respond to a defined class of thymus-independent antigens. The implication for vaccine use in humans is that a late-appearing subclass of B-cells may be required for adequate immune responses to polyaccharide antigens.

subject areas

  • Age Factors
  • Animals
  • Animals, Newborn
  • Antibodies, Bacterial
  • Antibody Formation
  • Antigens
  • Antigens, Bacterial
  • B-Lymphocytes
  • Brucella abortus
  • Lipopolysaccharides
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/136.Supplement.S14

PubMed ID

  • 408430
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Additional Document Info

start page

  • S14

end page

  • S19

volume

  • 136

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