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Immunobiology and pathogenesis of hepatocellular injury in hepatitis-B virus transgenic mice

Academic Article
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Overview

authors

  • Moriyama, T.
  • Guilhot, S.
  • Klopchin, K.
  • Moss, B.
  • Pinkert, C. A.
  • Palmiter, R. D.
  • Brinster, R. L.
  • Kanagawa, O.
  • Chisari, Francis

publication date

  • April 1990

journal

  • Science  Journal

abstract

  • The role of the immune response to hepatitis B virus (HBV)-encoded antigens in the pathogenesis of liver cell injury has not been defined because of the absence of appropriate experimental models. HBV envelope transgenic mice were used to show that HBV-encoded antigens are expressed at the hepatocyte surface in a form recognizable by major histocompatibility complex (MHC) class I-restricted, CD8+ cytotoxic T lymphocytes specific for a dominant T cell epitope within the major envelope polypeptide and by envelope-specific antibodies. Both interactions led to the death of the hepatocyte in vivo, providing direct evidence that hepatocellular injury in human HBV infection may also be immunologically mediated.

subject areas

  • Amino Acid Sequence
  • Animals
  • Cell Line, Transformed
  • Cytotoxicity, Immunologic
  • Epitopes
  • Hepatitis B
  • Hepatitis B Surface Antigens
  • Histocompatibility Antigens Class I
  • Liver
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Simian virus 40
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes, Regulatory
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1691527

PubMed ID

  • 1691527
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Additional Document Info

start page

  • 361

end page

  • 364

volume

  • 248

issue

  • 4953

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