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Macrophage requirement for the in vitro response to TNP Ficoll: a thymic independent antigen

Academic Article
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Overview

authors

  • Chused, T. M.
  • Kassan, S. S.
  • Mosier, Donald

publication date

  • 1976

journal

  • Journal of Immunology  Journal

abstract

  • The in vitro antibody-forming cell response of mouse spleen cells to the thymic independent synthetic polymer, TNP-Ficoll, was found to require the presence of either macrophages or 2-mercaptoethanol. The TNP-Ficoll response and that to the thymic dependent antigen, sheep erythrocytes, demonstrated the same degree of macrophage dependence. However, macrophage-depleted spleen cells which did not produce plaque-forming cells responded normally to T and B cell mitogens. Comparison of the antibody-forming cell response of macrophage-depleted spleen cells in the presence and absence of 2-mercaptoethanol indicated that either macrophages function 10 to 100 times more efficiently in its presence or that 2-mercaptoethanol partially replaces the function of macrophages.

subject areas

  • Animals
  • Antibody Formation
  • Erythrocytes
  • Ficoll
  • Hemolytic Plaque Technique
  • In Vitro Techniques
  • Macrophages
  • Mercaptoethanol
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Nitrobenzenes
  • Polysaccharides
  • Sheep
  • Thymus Gland
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 774987
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Additional Document Info

start page

  • 1579

end page

  • 1581

volume

  • 116

issue

  • 6

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