The scope of antibody catalysis

Academic Article
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publication date

  • December 1995

abstract

  • New strategies for hapten design have led to antibodies that catalyze reactions by increasingly complex mechanisms and with large increases in catalytic rate. Rational design has also been used to elicit catalytic antibodies for difficult chemical transformations as well as reactions for which no enzyme is known. These experiments have demonstrated the chemical potential of large combinatorial libraries that have been given appropriate mechanistic instruction.