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Cytokine receptor dimerization and activation: prospects for small molecule agonists

Academic Article
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Overview

related to degree

  • Goldberg, Joel, Ph.D. in Chemistry, Scripps Research 1994 - 2000

authors

  • Boger, Dale
  • Goldberg, Joel

publication date

  • March 2001

journal

  • Bioorganic & Medicinal Chemistry  Journal

abstract

  • Ligand-induced dimerization of cell surface receptors has emerged as a general mechanism for the initiation of signal transduction. A number of therapeutically important receptor families are believed to be activated by this process. Recently available structural information, particularly for the erythropoietin receptor, has provided insight into the mechanism of receptor activation. These findings have also revealed important constraints on the nature of receptor-agonist complexes. The prospects of discovering small-molecule mimetics of such receptor agonists are discussed, including strategies which have led to the identification of a small number of peptide and non-peptide cytokine mimetics.

subject areas

  • Animals
  • Dimerization
  • Humans
  • Ligands
  • Receptors, Cytokine
  • Receptors, Erythropoietin
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/s0968-0896(00)00276-5

PubMed ID

  • 11310589
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Additional Document Info

start page

  • 557

end page

  • 562

volume

  • 9

issue

  • 3

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