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Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease

Academic Article
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Overview

authors

  • Oldstone, Michael
  • Lewicki, H.
  • Thomas, D.
  • Tishon, A.
  • Dales, S.
  • Patterson, J.
  • Manchester, Marianne
  • Homann, D.
  • Naniche, D.
  • Holz, A.

publication date

  • September 1999

journal

  • Cell  Journal

abstract

  • Measles virus (MV) infects 40 million persons and kills one million per year primarily by suppressing the immune system and afflicting the central nervous system (CNS). The lack of a suitable small animal model has impeded progress of understanding how MV causes disease and the development of novel therapies and improved vaccines. We tested a transgenic mouse line in which expression of the MV receptor CD46 closely mimicked the location and amount of CD46 found in humans. Virus replicated in and was recovered from these animals' immune systems and was associated with suppression of humoral and cellular immune responses. Infectious virus was recovered from the CNS, replicated primarily in neurons, and spread to distal sites presumably by fast axonal transport. Thus, a small animal model is available for analysis of MV pathogenesis.

subject areas

  • Animals
  • Antigens, CD
  • Antigens, CD46
  • Brain
  • Cells, Cultured
  • Central Nervous System Infections
  • Chromosomes, Artificial, Yeast
  • Disease Models, Animal
  • Dose-Response Relationship, Immunologic
  • Flow Cytometry
  • Immunosuppression
  • Lymph Nodes
  • Lymphocytes
  • Measles
  • Measles virus
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Microscopy, Electron
  • Neurons
  • Spleen
  • Time Factors
  • Tissue Distribution
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80050-1

PubMed ID

  • 10490102
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Additional Document Info

start page

  • 629

end page

  • 640

volume

  • 98

issue

  • 5

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