Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Clonal restriction of platelet-associated anti-gpiib/iiia autoantibodies in patients with chronic itp

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mc Millan, Robert
  • Lopez-Dee, J.
  • Bowditch, R.

publication date

  • May 2001

journal

  • Thrombosis and Haemostasis  Journal

abstract

  • Chronic immune thrombocytopenic purpura is due to platelet destruction induced by autoantibodies against platelet surface antigens. Prior studies show that some serum autoantibodies are light-chain restricted, suggesting a clonal origin. Since plasma and platelet-associated antibody from the same patient may bind to different epitopes. it is important to evaluate the clonality of platelet-associated antibody. Platelet-associated autoantibodies from 28 ITP patients were studied. Of 23 platelet-associated antibodies tested directly, 16 showed significant light chain restriction (7 complete and 9 partial) when compared to plasma IgG light chain distribution. Similarly, 9 of 12 platelet-associated antibody eluates were light chain restricted, 5 complete and 4 partial. In all cases where platelet-associated antibody and antibody eluate from the same patient were studied, the results were concordant. We conclude that a significant proportion of platelet-associated antibodies from ITP patients show apparent clonality, as evaluated by light chain restriction. These results are consistent with other studies in ITP suggesting a limited antigenic repertoire.

subject areas

  • Adult
  • Aged
  • Autoantibodies
  • Blood Platelets
  • Chronic Disease
  • Clone Cells
  • Epitopes
  • Female
  • Humans
  • Immunoglobulin Light Chains
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Male
  • Middle Aged
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Purpura, Thrombocytopenic, Idiopathic
scroll to property group menus

Research

keywords

  • ITP
  • autoantibody
  • clonality
  • platelet
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0340-6245

PubMed ID

  • 11372674
scroll to property group menus

Additional Document Info

start page

  • 821

end page

  • 823

volume

  • 85

issue

  • 5

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support