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Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing

Academic Article
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Overview

related to degree

  • Kaufmann, Gunnar, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Kaufmann, Gunnar
  • Sartorio, R.
  • Lee, S. H.
  • Mee, J. M.
  • Altobell, L. J.
  • Kujawa, D. P.
  • Jeffries, E.
  • Clapham, B.
  • Meijler, M. M.
  • Janda, Kim

publication date

  • March 2006

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Many bacterial pathogens coordinate their virulence factor expression in a cell density-dependent manner. This population-dependent coordination of gene expression in bacteria has been termed "quorum sensing" (QS). N-Acyl homoserine lactones (AHLs) are used by over 70 Gram-negative bacterial species as autoinducers. Inhibition of QS signaling might represent a new target for antimicrobial therapy. Here we report the hapten design, synthesis, generation of monoclonal antibodies (mAbs) against AHLs, and the evaluation of these mAbs for their ability to blunt QS signaling and inhibit virulence factor expression in P. aeruginosa. The mAbs can be envisioned as a tool for future investigations into AHL-based QS, which may aid in gaining new insights into the pathogenesis of P. aeruginosa and may ultimately lead to the development of new strategies to combat bacterial diseases.

subject areas

  • 4-Butyrolactone
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Gene Expression Regulation, Bacterial
  • Haptens
  • Pseudomonas aeruginosa
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Identity

PubMed Central ID

  • PMC2546487

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja0578698

PubMed ID

  • 16506750
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Additional Document Info

start page

  • 2802

end page

  • 2803

volume

  • 128

issue

  • 9

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