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A key role for corticotropin-releasing factor in alcohol dependence

Academic Article
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Overview

authors

  • Heilig, M.
  • Koob, George

publication date

  • August 2007

journal

  • Trends in Neurosciences  Journal

abstract

  • Recent data indicate that alcohol dependence induces long-term neuroadaptations that recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by relief of negative emotionality. A key mechanism in this transition to negative reinforcement is a recruitment of corticotropin-releasing factor (CRF) signaling within the amygdala. Long term upregulation of CRF(1) receptors is observed in the amygdala following a history of dependence, and CRF antagonists selectively block emotionality, excessive alcohol drinking and stress-induced reinstatement of alcohol-seeking in post-dependent animals. Innate upregulation of CRF(1) receptor expression mimics the post-dependent phenotype, both with regard to emotional responses and ethanol self-administration. Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment.

subject areas

  • Adaptation, Physiological
  • Affect
  • Alcohol-Related Disorders
  • Amygdala
  • Animals
  • Behavior, Addictive
  • Corticotropin-Releasing Hormone
  • Ethanol
  • Humans
  • Reward
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Identity

PubMed Central ID

  • PMC2747092

International Standard Serial Number (ISSN)

  • 0166-2236

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2007.06.006

PubMed ID

  • 17629579
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Additional Document Info

start page

  • 399

end page

  • 406

volume

  • 30

issue

  • 8

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