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An essential role for type-1 interferon-gamma in terminating persistent viral-infection

Academic Article
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Overview

authors

  • Tishon, A.
  • Lewicki, H.
  • Rall, G.
  • Vonherrath, M.
  • Oldstone, Michael

publication date

  • September 1995

journal

  • Virology  Journal

abstract

  • The mechanism(s) by which infectious material is cleared by the host is an area of intensive study. This is especially so with the realization that persistent viral infection is a cause of chronic disease in humans and presents a major health problem. We have used the murine model of infection with lymphocytic choriomeningitis virus to evaluate immune clearance. Mice with a targeted disruption of the IFN-gamma gene mount effective cytotoxic T lymphocyte (CTL) responses after an acute viral challenge and clear virus. CD4+ T cells are not required but CD8+ T cells are mandatory. In contrast, CTL from mice with targeted disruption of the IFN-gamma gene are unable to clear virus from persistently infected mice. In addition to the requirement for IFN-gamma, CD4+ T cells are essential for maintaining a CD8(+)-mediated cure of persistent viral infection.

subject areas

  • Animals
  • Antibodies, Viral
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Chronic Disease
  • Immunity, Cellular
  • Immunoglobulin G
  • Immunologic Memory
  • Interferon-gamma
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • RNA, Viral
  • T-Lymphocytes, Cytotoxic
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Identity

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1006/viro.1995.1477

PubMed ID

  • 7676639
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Additional Document Info

start page

  • 244

end page

  • 250

volume

  • 212

issue

  • 1

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