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An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis

Academic Article
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Overview

authors

  • Isomura, S.
  • Wirsching, P.
  • Janda, Kim

publication date

  • June 2001

journal

  • Journal of Organic Chemistry  Journal

abstract

  • People continue to smoke and use tobacco products despite well-established hazardous consequences. The most contributing factor is the addictive nature of nicotine. There is no highly effective treatment for the problem of nicotine dependence. Immunotherapy offers an alternative to conventional approaches. The chemistry necessary for a comprehensive immunopharmacological program is presented. Haptens for the generation of antibodies specific for naturally occurring (S)-nicotine, (S)- and (R)-nornicotine, and the metabolite (S)-cotinine were prepared with high optical purity. Preliminary data for antinicotine antibodies are reported.

subject areas

  • Haptens
  • Humans
  • Immunotherapy
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Nicotine
  • Substance-Related Disorders
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Identity

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo001442w

PubMed ID

  • 11397142
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Additional Document Info

start page

  • 4115

end page

  • 4121

volume

  • 66

issue

  • 12

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