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The anemia of ageing is not associated with increased plasma hepcidin levels

Academic Article
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Overview

authors

  • Lee, Pauline
  • Gelbart, T.
  • Waalen, Jill
  • Beutler, Ernest

publication date

  • 2008

journal

  • Blood Cells Molecules and Diseases  Journal

abstract

  • It has been proposed that the anemia of ageing may be caused, at least in part, by elevated hepcidin levels, representing a response to increased IL-6 levels. Using a recently developed immunoassay, we have measured the plasma hepcidin levels of eight patients with the anemia of ageing and sex- and age-matched controls, and found that the levels of hepcidin were not increased in patients with the anemia of ageing. In contrast, patients with the anemia of inflammation have higher hepcidin levels than sex- and age-matched controls. In the overall group there was a strong correlation between serum ferritin levels and hepcidin levels, as has been found previously.

subject areas

  • Aged
  • Aged, 80 and over
  • Aging
  • Anemia
  • Anemia, Iron-Deficiency
  • Antimicrobial Cationic Peptides
  • Case-Control Studies
  • Female
  • Ferritins
  • Hepcidins
  • Humans
  • Inflammation
  • Interleukin-6
  • Male
  • Middle Aged
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Identity

International Standard Serial Number (ISSN)

  • 1079-9796

Digital Object Identifier (DOI)

  • 10.1016/j.bcmd.2008.06.005

PubMed ID

  • 18676162
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Additional Document Info

start page

  • 252

end page

  • 254

volume

  • 41

issue

  • 3

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